Canine ACE2/hFc antibody and antigen (recombinant protein) GMP-CAN-ACE2-hFc

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Product information

Size： 1mg | 10mg | 100mg

Catalog No.	Description	US $ Price (per mg)	First Order Discount	First Order Discount Price
GMP-CAN-ACE2/hFc-Ag01	Recombinant Canine ACE2/hFc protein	3090
GMP-CAN-ACE2/hFc-Ab01	Anti-Canine ACE2/hFc mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-ACE2/hFc-Ab02	Anti-Canine ACE2/hFc mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-ACE2/hFc-Ab03	Anti-Canine ACE2/hFc mouse monoclonal antibody (mAb)	1953	20%	1562.4
GMP-CAN-ACE2/hFc-Ab04	Anti-Canine ACE2/hFc mouse monoclonal antibody (mAb)	1953	20%	1562.4

Shipping Costs: $360–$760
Antibodies: $360 Antigens: $760 (Elevated cost due to antigen heterogeneity, post-translational modifications, structural complexity, and specialized handling.)

Product Description

Cat No. of Products	GMP-CAN-ACE2/hFc-Ag01
Product Name	Recombinant Canine ACE2/hFc protein
Target/Biomarker	Canine Angiotensin Converting Enzyme 2 (ACE2/hFc)
Expression platform	E.coli
Isotypes	Recombinant Antigen
Bioactivity validation	Anti-Canine Angiotensin Converting Enzyme 2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in ACE2/hFc level test of animal Dog/Canine with acute respiratory distress syndrome.
Tag	His
Products description	Recombinant Canine ACE2/hFc protein was expressed in E.coli - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	PBS liquid / Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Cat No. of Products	GMP-CAN-ACE2/hFc-Ab01, GMP-CAN-ACE2/hFc-Ab02, GMP-CAN-ACE2/hFc-Ab03, GMP-CAN-ACE2/hFc-Ab04
Product Name	Anti-Canine ACE2/hFc mouse monoclonal antibody (mAb)
Target/Biomarker	Canine Angiotensin Converting Enzyme 2 (ACE2/hFc)
Expression platform	CHO
Isotypes	Mouse IgG
Bioactivity validation	Anti-Canine Angiotensin Converting Enzyme 2 antibodies binding, Immunogen in Sandwich Elisa, lateral-flow tests, and other immunoassays as control material in ACE2/hFc level test of animal Dog/Canine with acute respiratory distress syndrome.
Tag	mFc
Products description	Anti-Canine ACE2/hFc mouse monoclonal antibody (mAb) was expressed in CHO - based prokaryotic cell expression system and is expressed with 6 HIS tag at the C-terminus.
Purity	Purity: ≥95% (SDS-PAGE)
Application	Paired antibody immunoassay validation in sandwich Elisa, ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA, POCT and other immunoassays
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Click to get more Data / Case study about the product.

Target/Biomarker information

Canine ACE2/hFc, a fusion protein at the intersection of canine physiology and molecular research, emerges as an instrument of remarkable significance. Its composite nature comprises two distinct components: Canine ACE2 (Angiotensin-Converting Enzyme 2) and the human immunoglobulin Fc region (hFc). Together, they offer a multidimensional lens through which to examine the physiology of dogs and their susceptibility to zoonotic diseases. Canine ACE2, the foundational element of this fusion protein, is an integral component of the Renin-Angiotensin System (RAS) in dogs. As a membrane-bound metallopeptidase, it wields substantial influence over the regulation of blood pressure, fluid balance, and cardiovascular homeostasis. Canine ACE2 achieves this by catalyzing the conversion of Angiotensin II, a potent vasoconstrictor, into Angiotensin 1-7, a vasodilator. This enzymatic equilibrium serves as a fulcrum in the intricate dance of canine cardiovascular physiology. The "hFc" component, on the other hand, adds an intriguing layer of utility to Canine ACE2/hFc. This fusion with the human immunoglobulin Fc region amplifies the protein's versatility in laboratory settings. It endows researchers with the capacity to efficiently detect, purify, and manipulate the protein, thus facilitating a deeper dive into the realms of canine molecular biology. One of the most notable aspects of Canine ACE2/hFc is its relevance in zoonotic research. The fusion protein serves as a key tool for investigating the interactions between canine ACE2 receptors and various pathogens, with a particular focus on coronaviruses. This is of profound significance in light of zoonotic diseases like SARS-CoV-2, where the susceptibility of dogs to infection has raised critical questions about transmission dynamics and preventive strategies.

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