Human serum albumin(HSA) antibody/antigen (BSA/OVA/KLH conjugated hapten)

 Download 

anti-Human serum albumin(HSA) antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

Go to Allergen diagnostics products collection >>

Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Human serum albumin(HSA)

OVA-Human serum albumin(HSA)

Anti-Human serum albumin(HSA) mouse monoclonal antibody

Anti-Human serum albumin(HSA) human monoclonal antibody

Reference

Validation Data

Click to get more Data / Case study about the product.

Biomarker Information

1. Human Serum Albumin (HSA) - A Comprehensive Insight

1.1 Overview of HSA:



Human Serum Albumin (HSA) is a ubiquitous and indispensable blood plasma protein, constituting approximately 60% of the total plasma proteins. This abundant protein is primarily synthesized by the hepatic cells, and its presence in the bloodstream plays a pivotal role in maintaining various physiological functions.

HSA, a single-chain polypeptide with 585 amino acid residues, boasts remarkable versatility in binding various molecules, making it a versatile carrier protein within the circulatory system. With its critical role in molecular transport and homeostasis, HSA serves as an anchor of systemic equilibrium.

1.2 HSA's Significance in Allergens:

In the context of allergens, HSA emerges as a key player in facilitating immune responses and understanding allergic reactions. Its unique ability to bind to small molecules, including allergenic substances, enhances the immune system's capability to detect and respond to these threats effectively.

When allergens, such as pollen or specific food proteins, enter the body, they can become conjugated or bound to HSA. This binding, or haptenation, plays a critical role in antigen recognition by the immune system. The immune system relies on the presentation of allergens by HSA to mount an appropriate immune response. Thus, HSA acts as an indispensable carrier molecule, ensuring the efficient transport and recognition of allergens by immune cells. This phenomenon is of paramount importance in elucidating the mechanisms behind allergic reactions and underpins the development of diagnostic tests and therapeutic interventions for allergies.

Further research into the intricate interplay between HSA and allergens contributes to a deeper understanding of allergic responses, enabling the development of targeted treatments and allergen-specific diagnostics.

2. The Imperative of HSA Measurement

2.1 Nutritional Assessment:

The quantification of Human Serum Albumin (HSA) levels is instrumental in the clinical assessment of an individual's nutritional status. As HSA is primarily produced in the liver and plays a crucial role in maintaining plasma oncotic pressure, variations in its concentration can provide valuable insights into a patient's nutritional health.

Low HSA levels may indicate malnutrition, chronic illnesses, or inflammatory conditions. Conversely, elevated HSA levels can be observed in acute dehydration or during certain medical treatments. Thus, measuring HSA levels offers healthcare professionals a window into a patient's nutritional well-being and can guide appropriate dietary interventions and therapeutic strategies.

2.2 Liver Function Monitoring:

Given its hepatic origin, HSA is intrinsically tied to liver function. Monitoring HSA levels in the blood can serve as a sensitive marker for hepatic health and disorders. The liver's ability to synthesize HSA is influenced by its overall function, and deviations from the normal range can provide early indications of liver pathologies.

Reduced HSA levels can occur in chronic liver diseases, cirrhosis, or other conditions affecting liver function. On the contrary, in acute conditions like liver injury or hepatitis, HSA levels may temporarily increase due to the liver's response to inflammation. Therefore, regular measurement of HSA levels is a valuable tool for clinicians in the assessment, diagnosis, and management of liver diseases.

2.3 Pharmaceutical Research Utility:

In the realm of pharmaceutical research and drug development, the measurement of HSA plays a crucial role in elucidating the pharmacokinetics and drug-protein binding interactions. HSA's affinity for binding various drugs impacts their distribution, metabolism, and elimination within the body.

Researchers utilize HSA as a model protein to assess drug-protein interactions, predict drug behavior in vivo, and optimize drug formulations. Understanding how drugs interact with HSA aids in designing more effective and safe pharmaceuticals, determining appropriate dosages, and evaluating potential drug-drug interactions. This knowledge is integral to the development and approval of novel therapeutic agents.

2.4 Allergy Research and Immunogen Studies:

In the realm of biopharmaceuticals and immunology, HSA assumes a unique role as a carrier molecule for small molecules and antigens. This application involves the conjugation of small molecules or antigens to HSA, producing antigen-HSA conjugates. These conjugates are invaluable in generating antibodies, immunogens, and diagnostic tools.

Measuring HSA levels is a critical aspect of this process, ensuring the successful development and production of antigen-HSA conjugates. The resulting conjugates are used in diverse applications, including research, diagnostics, and therapeutic antibody development. Accurate HSA measurement is crucial to maintain the integrity and consistency of these conjugates, enabling precise and reproducible results in various scientific endeavors.

In summation, the measurement of Human Serum Albumin (HSA) is an interdisciplinary imperative, spanning the domains of nutrition, liver health, pharmaceutical research, allergy studies, and biopharmaceutical advancements. With its multifaceted roles and applications, HSA stands as an invaluable biomarker and carrier molecule, driving innovation and enhancing our understanding of biological processes and human health.

About GDU