Quinolone antibody/antigen (BSA/OVA/KLH conjugated hapten)

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anti-Quinolone antibody and Carrier-coupled antigen/immunogen (hapten-carrier conjugates)

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Product information

Size： 1mg | 10mg | 100mg

Product Description

BSA-Quinolone

OVA-Quinolone

Anti-Quinolone mouse monoclonal antibody

Anti-Quinolone human monoclonal antibody

Reference

Validation Data

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Biomarker Information

Quinolone and Its Environmental Significance:

Quinolones, a class of bicyclic compounds, have emerged as significant subjects of study in environmental science and biopharmaceutical research. Their prevalence in the environment is primarily attributed to the extensive use of quinolone-based antibiotics in both human and veterinary medicine. Quinolones belong to a larger group of compounds known as fluoroquinolones, and they have a distinct chemical structure characterized by a bicyclic ring system.

Quinolone antibiotics, such as ciprofloxacin and levofloxacin, are widely used to treat a variety of bacterial infections in humans and animals. However, the widespread use of these antibiotics has raised concerns about their environmental impact. The compounds are excreted by patients and animals into wastewater, which eventually finds its way into natural water bodies, including rivers, lakes, and groundwater. This process leads to the contamination of aquatic ecosystems, raising concerns about the ecological impact and potential risks to public health (1).

2. Importance of Quinolone Measurement:

Accurate measurement of quinolones is crucial for various reasons, including environmental assessment, antibiotic resistance studies, and pharmaceutical research and compliance.

a. Environmental Assessment (2): Accurate measurement of quinolones is essential for evaluating their presence and concentration in environmental matrices. This assessment aids in understanding the extent of contamination and devising appropriate remediation strategies. High-performance analytical methods are required to detect quinolones in environmental samples, as their concentrations can be extremely low in aquatic ecosystems. Sensitive detection methods enable researchers to track the fate and transport of these compounds in the environment, providing valuable data for regulatory agencies and environmental scientists.

b. Antibiotic Resistance Studies: Quinolones are pivotal in the emergence of antibiotic-resistant bacteria. Monitoring quinolone levels is essential to discern patterns in resistance development and formulate effective interventions. The overuse and misuse of quinolone antibiotics in clinical and agricultural settings have led to the development of antibiotic-resistant strains of bacteria. Measuring quinolone concentrations in various environments, including hospitals, farms, and wastewater treatment plants, is critical for understanding the dynamics of antibiotic resistance and devising strategies to mitigate its spread (3).

c. Pharmaceutical Research and Compliance: In the pharmaceutical industry, quinolones are integral components of various drug formulations, making their accurate measurement crucial for product quality and safety. Regulatory agencies, such as the U.S. Food and Drug Administration (FDA), have established strict guidelines for the pharmaceutical industry to ensure the safety and efficacy of medicinal products. Reliable analytical methods for quinolone measurement are required to comply with these regulations. Pharmaceutical companies rely on precise quantification of quinolones to meet quality control standards and maintain the integrity of their products (4).

3. Advanced Solutions for Quinolone Measurement:

To address the need for accurate and sensitive quinolone measurement, our company offers advanced solutions, including anti-quinolone antibodies and small molecule competitive antigens like Carrier-coupled antigens and hapten-carrier conjugates. These resources empower researchers to develop highly sensitive assays for quinolone detection, which is crucial for environmental monitoring, antibiotic resistance studies, and pharmaceutical research.

a. Anti-Quinolone Antibodies: These antibodies are designed to specifically bind to quinolones, enabling the development of immunoassays for quinolone detection. Immunoassays are highly sensitive and selective methods that can detect trace amounts of quinolones in complex environmental samples. These antibodies can be used in various immunoassay formats, including enzyme-linked immunosorbent assays (ELISA) and lateral flow assays, providing flexibility for different research needs (5).

b. Small Molecule Competitive Antigens: Carrier-coupled antigens and hapten-carrier conjugates are critical components in competitive immunoassays for quinolones. These antigens mimic the structure of quinolones, allowing them to compete with the target quinolones for binding to anti-quinolone antibodies. This competitive binding results in a signal that is inversely proportional to the quinolone concentration, making it a quantitative indicator of quinolone levels in a sample. Small molecule antigens offer a cost-effective and reproducible means of quantifying quinolones with high sensitivity (6).

4. Conclusion:

In summary, quinolones have become subjects of increasing importance in environmental science and biopharmaceutical research due to their widespread use and potential environmental consequences. The accurate measurement of quinolones is essential for environmental assessment, antibiotic resistance studies, and pharmaceutical research and compliance. Advanced solutions, such as anti-quinolone antibodies and small molecule competitive antigens, provide researchers with the tools needed to develop sensitive assays for quinolone detection. These tools play a crucial role in understanding and mitigating the impact of quinolones in our environment and ensuring the safety and efficacy of pharmaceutical products. Accurate and sensitive quinolone measurement is a key component in addressing the challenges posed by these compounds in both environmental and healthcare contexts (7).

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