It's the GeneMedi's summary page for Target/Biomarker Introduction of CA-XII,CA12. The page also collects GeneMedi's different modalities and formats products for CA-XII in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the CA-XII target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014]

Target IDGM-T16987
Target NameCA-XII
Gene ID771
Gene Official NameCA12
Gene AliasCA-XII, CAXII, HsT18816, T18816
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target

Pre-made anti-CA-XII inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark reference antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-CA-XII benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-CA-XII mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.Antibody NameFormatClassified by tagOrder
GM-Tg-hg-T16987-AbAnti-CA-XII/CA12 monoclonal antibodymabBiofunctional antibody, Therapeutics Target antibodymonoclonal antibody.

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