EGFR vIII/EGFR: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of EGFR vIII/EGFR. The page also collects GeneMedi's different modalities and formats products for EGFR vIII in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the EGFR vIII target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]
|Target Name||EGFR vIII|
|Gene Symbol and Synonyms||9030024J15Rik,EGFR,ERBB,ErbB-1,ERBB1,Errb1,ERRP,HER1,mENA,NISBD2,PIG61,wa-2,wa2,Wa5|
|Uniprot Entry Name||EGFR_HUMAN,EGFR_MACMU|
|Protein Sub-location||Transmembrane Protein|
|Disease||Breast Cancer, Non-Small Cell Lung Cancer, gastric cancer, apoptosis, Asphyxia neonatorum, Urinary bladder urothelial carcinoma|
Pre-made anti-EGFR vIII inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-EGFR vIII benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-EGFR vIII mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
|Antibody Name||Species||Format||Classified by tag||Detail|
|Anti-EGFR vIII/EGFR monoclonal antibody||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||mab||FACS/Biofunctional Antibody||Detail|
Multi-species EGFR/ EGFR vIII/ ERBB VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine EGFR vIII/EGFR VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
|Products Name||Species||Expression Platform||Detail|
|EGFR vIII/EGFR VLP (virus-like particle)||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||Mammalian cell||Products Developing|
Pre-made EGFR viral vector in GM Promise-ORFTM
|Cat No.||Products name||NM ID||Species||Type||Detail|
|pGMLV000508||human EGFR Lentivirus plasmid||NM_005228.4||Human||Lentivirus plasmid||Detail|
|vGMLV000508||human EGFR Lentivirus particle||NM_005228.4||Human||Lentivirus particle||Detail|
|pGMAD000182||human EGFR Adenovirus plasmid||NM_005228.3||Human||Adenovirus plasmid||Detail|
|pGMLV000217||human EGFR Lentivirus plasmid||NM_005228.3||Human||Lentivirus plasmid||Detail|
|vGMLV000217||human EGFR Lentivirus particle||NM_005228.3||Human||Lentivirus particle||Detail|
|vGMLV000216||human EGFR Lentivirus particle||NM_005228.4||Human||Lentivirus particle||Detail|
|pGMLV000216||human EGFR Lentivirus plasmid||NM_005228.4||Human||Lentivirus plasmid||Detail|
|vGMAD000182||human EGFR Adenovirus particle||NM_005228.3||Human||Adenovirus particle||Detail|
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.