Entrez Gene ID Official Symbol Species Alias Names Background
983 Kinase CDC2; CDC28A; P34CDC2 cyclin-dependent kinase 1 [ Homo sapiens (human) ]
8558 Kinase PISSLRE cyclin-dependent kinase 10 [ Homo sapiens (human) ]
984 Kinase CDC-related protein kinase p58; CDC2L1; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CLK-1; PITSLRE serine/threonine-protein kinase CDC2L1; PITSLREA; PK58; cell division cycle 2-like 1 (PITSLRE proteins); cell division cycle 2-like protein kinase 1; cell division protein kinase 11B; cyclin-dependent kinase 11B; galactosyltransferase-associated protein kinase p58/GTA; p58; p58 CLK-1; p58CDC2L1; p58CLK-1 This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L2, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L2, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L2 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported. [provided by RefSeq, Jul 2008]
51755 Kinase CRK7; CRKR; CRKRS cyclin-dependent kinase 12 isoform 2 [Homo sapiens]
8621 Kinase CDC2-related protein kinase 5; CDC2L; CDC2L5; CHED; cell division cycle 2-like 5 (cholinesterase-related cell division controller); cell division cycle 2-like protein kinase 5; cell division protein kinase 13; cholinesterase-related cell division controller; cyclin-dependent kinase 13; hCDK13 The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]
5218 Kinase PFTAIRE protein kinase 1; PFTAIRE1; PFTK1; cell division protein kinase 14; cyclin-dependent kinase 14; hPFTAIRE1; serine/threonine-protein kinase PFTAIRE-1 PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]
65061 Kinase ALS2CR7; PFTAIRE protein kinase 2; PFTAIRE2; PFTK2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein; cell division protein kinase 15; cyclin-dependent kinase 15; serine/threonine protein kinase; serine/threonine-protein kinase ALS2CR7; serine/threonine-protein kinase PFTAIRE-2 Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin (By similarity).
5127 Kinase PCTAIRE; PCTAIRE protein kinase 1; PCTAIRE-motif protein kinase 1; PCTAIRE1; PCTGAIRE; PCTK1; cell division protein kinase 16; cyclin-dependent kinase 16; serine/threonine-protein kinase PCTAIRE-1 The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
5128 Kinase PCTAIRE protein kinase 2; PCTAIRE-motif protein kinase 2; PCTAIRE2; PCTK2; cell division protein kinase 17; cyclin-dependent kinase 17; protein kinase cdc2-related PCTAIRE-2; serine/threonine-protein kinase PCTAIRE-2 The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]
5129 Kinase PCTAIRE; PCTAIRE protein kinase 3; PCTAIRE-motif protein kinase 3; PCTAIRE3; PCTK3; cell division protein kinase 18; cyclin-dependent kinase 18; serine/threonine-protein kinase PCTAIRE-3 May play a role in signal transduction cascades in terminally differentiated cells.
23097 Kinase CDC2-related protein kinase 6; CDC2L6; CDK11; CDK8-like cyclin-dependent kinase; bA346C16.3; cell division cycle 2-like 6 (CDK8-like); cell division cycle 2-like protein kinase 6; cell division protein kinase 19; cyclin-dependent kinase (CDC2-like) 11; cyclin-dependent kinase 11; cyclin-dependent kinase 19; death-preventing kinase This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. [provided by RefSeq, Jul 2008]
1017 Kinase cdc2-related protein kinase; cell devision kinase 2; cell division protein kinase 2; cyclin-dependent kinase 2; p33 protein kinase; p33(CDK2) The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
23552 Kinase P42; CCRK; CDCH; PNQALRE cyclin-dependent kinase 20 [ Homo sapiens (human) ]
1018 Kinase cell division protein kinase 3; cyclin-dependent kinase 3 This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
1019 Kinase CMM3; PSK-J3; cell division protein kinase 4; cyclin-dependent kinase 4 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
1019 Kinase CMM3; PSK-J3; cell division protein kinase 4; cyclin-dependent kinase 4 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
1019 Kinase CMM3; PSK-J3; cell division protein kinase 4; cyclin-dependent kinase 4 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
1019 Kinase CMM3; PSK-J3; cell division protein kinase 4; cyclin-dependent kinase 4 The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
1020 Kinase PSSALRE; TPKII catalytic subunit; cell division protein kinase 5; cyclin-dependent kinase 5; protein kinase CDK5 splicing; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates m
1021 Kinase MCPH12; PLSTIRE cyclin-dependent kinase 6 [ Homo sapiens (human) ]