Kinase

Entrez Gene ID Official Symbol Species Alias Names Background
1022 Kinase 39 KDa protein kinase; CAK; CAK1; CDK-activating kinase 1; CDKN7; HCAK; MO15; STK1; TFIIH basal transcription factor complex kinase subunit; cell division protein kinase 7; cyclin-dependent kinase 7; cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase); cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase); homolog of Xenopus MO15 Cdk-activating kinase; kinase subunit of CAK; p39 Mo15; p39MO15; protein kinase; serine/threonine kinase stk1; serine/threonine protein kinase 1; serine/threonine protein kinase MO15; serine/threonine-protein kinase 1 The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008]
1024 Kinase CDK8 protein kinase; K35; cell division protein kinase 8; cyclin-dependent kinase 8; mediator complex subunit CDK8; mediator of RNA polymerase II transcription subunit CDK8; protein kinase K35 The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]
1025 Kinase C-2k; CDC2-related kinase; CDC2L4; CTK1; PITALRE; TAK; cell division cycle 2-like protein kinase 4; cell division protein kinase 9; cyclin-dependent kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); serine/threonine protein kinase PITALRE; serine/threonine-protein kinase PITALRE; tat-associated kinase complex catalytic subunit The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
8814 Kinase CDC2-related kinase 1; KKIALRE; P42; cyclin-dependent kinase-like 1; cyclin-dependent kinase-like 1 (CDC2-related kinase); protein kinase p42 KKIALRE; serine/threonine protein kinase KKIALRE; serine/threonine-protein kinase KKIALRE This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Alternative splice variants encoding different protein isoforms have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
8999 Kinase CDC2-related kinase; KKIAMRE; P56; cyclin-dependent kinase-like 2; cyclin-dependent kinase-like 2 (CDC2-related kinase); p56 KKIAMRE protein kinase; protein kinase p56 KKIAMRE; serine/threonine protein kinase KKIAMRE; serine/threonine-protein kinase KKIAMRE This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]
51265 Kinase NKIAMRE; cyclin-dependent kinase-like 3; serine-threonine protein kinase NKIAMRE; serine/threonine-protein kinase NKIAMRE The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
6792 Kinase EIEE2; ISSX; STK9; cyclin dependent kinase 5 transcript; cyclin-dependent kinase-like 5; serine/threonine kinase 9; serine/threonine-protein kinase 9 This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
812762 Kinase CDPK1; CPK; PFB0815w; PFCDPK1 Calcium-dependent protein kinase 1
1111 Kinase CHK1; CHK1 (checkpoint, S.pombe) homolog; CHK1 checkpoint homolog; CHK1 checkpoint homolog (S. pombe); Checkpoint, S. pombe, homolog of, 1; Chk1-S; cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase-1; serine/threonine-protein kinase Chk1 The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
11200 Kinase CDS1; CHK2; CHK2 (checkpoint, S.pombe) homolog; CHK2 checkpoint homolog; CHK2 checkpoint homolog (S. pombe); HuCds1; LFS2; PP1425; RAD53; cds1 homolog; checkpoint kinase 2; checkpoint-like protein CHK2; hCds1; protein kinase CHK2; serine/threonine-protein kinase Chk2 In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarc
1147 Kinase I-kappa-B kinase 1; I-kappa-B kinase-alpha; IKBKA; IKK-a kinase; IKK-alpha; IKK1; IKKA; IkB kinase alpha subunit; NFKBIKA; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; TCF16; conserved helix-loop-helix ubiquitous kinase; inhibitor of nuclear factor kappa-B kinase subunit alpha; transcription factor 16 This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor. [provided by RefSeq, Jul 2008]
null Kinase null null
null Kinase null null
11113 Kinase CRIK; STK21; citron (rho-interacting, serine/threonine kinase 21); citron Rho-interacting kinase; serine/threonine-protein kinase 21 This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
null Kinase C-Kit; CD117; PBT; SCFR; mast/stem cell growth factor receptor Kit; p145 c-kit; piebald trait; piebald trait protein; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; soluble KIT variant 1; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
null Kinase null null
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1198 Kinase CDC-like kinase 3; PHCLK3; PHCLK3/152; dual specificity protein kinase CLK3 This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
57396 Kinase CDC-like kinase 4; dual specificity protein kinase CLK4; protein serine threonine kinase Clk4 The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008]
null Kinase null null