Entrez Gene ID Official Symbol Species Alias Names Background
null Kinase null null
null Kinase CDHF12; CDHR16; HSCR1; Hirschsprung disease 1; MEN2A; MEN2B; MTC1; PTC; RET transforming sequence; RET-ELE1; RET51; cadherin family member 12; cadherin-related family member 16; hydroxyaryl-protein kinase; multiple endocrine neoplasia and medullary thyroid carcinoma 1; proto-oncogene c-Ret; proto-oncogene tyrosine-protein kinase receptor Ret; receptor tyrosine kinase; ret proto-oncogene; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) Only c-RAT got recongnised, not GFR2
null Kinase null null
1436 Kinase C-FMS; CD115; CD115 antigen; CSF-1 receptor; CSF-1-R; CSF-1R; CSFR; FIM2; FMS; FMS proto-oncogene; HDLS; M-CSF-R; McDonough feline sarcoma viral (v-fms) oncogene homolog; colony stimulating factor 1 receptor; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; proto-oncogene c-Fms The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
null Kinase null null
null Kinase CD114; CD114 antigen; G-CSF receptor; G-CSF-R; GCSFR; colony stimulating factor 3 receptor (granulocyte); granulocyte colony-stimulating factor receptor null
1445 Kinase C-Src kinase; c-src tyrosine kinase; protein-tyrosine kinase CYL; tyrosine-protein kinase CSK Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
1452 Kinase CK1; CK1a; CK1alpha; CKI-alpha; CKIa; CKIalpha; HLCDGP1; PRO2975; casein kinase 1, alpha 1; casein kinase I isoform alpha; clock regulator kinase; down-regulated in lung cancer Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May play a role in segregating chromosomes during mitosis.
122011 Kinase CK1; CKI-alpha-like; casein kinase 1, alpha 1-like; casein kinase I alpha S-like; casein kinase I isoform alpha-like Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).
null Kinase null null
1454 Kinase CKI-epsilon; CKIe; CKIepsilon; HCKIE; casein kinase 1, epsilon; casein kinase I isoform epsilon The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
53944 Kinase CK1gamma1; CKI-gamma 1; casein kinase 1, gamma 1; casein kinase I isoform gamma-1 This gene encodes a member of the casein kinase I gene family. The encoded protein is a serine/threonine kinase that phosphorylates acidic proteins, and participates in pathways for cell growth. [provided by RefSeq, Nov 2011]
1455 Kinase CK1g2; CKI-gamma 2; casein kinase 1 isoform gamma-2; casein kinase 1, gamma 2; casein kinase I isoform gamma-2 Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.
1456 Kinase CKI-gamma 3; casein kinase 1, gamma 3; casein kinase I isoform gamma-3 Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity).
1457 Kinase CK II alpha; CK2 catalytic subunit alpha; CK2A1; CKII; casein kinase 2, alpha 1 polypeptide; casein kinase II alpha 1 subunit; casein kinase II subunit alpha; protein kinase CK2 Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
1459 Kinase CK II alpha'; CK2A2; CSNK2A1; casein kinase 2, alpha prime polypeptide; casein kinase II subunit alpha' Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apopotosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activa
1612 Kinase DAP kinase 1; DAPK; death-associated protein kinase 1 Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. [provided by RefSeq, Jul 2008]
23604 Kinase DAP kinase 2; DAP-kinase-related protein 1 beta isoform; DRP-1; DRP1; death-associated protein kinase 2 This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq, Jul 2008]
1613 Kinase DAP kinase 3; DAP-like kinase; MYPT1 kinase; ZIP; ZIP kinase isoform; ZIP-kinase; ZIPK; death-associated protein kinase 3; dlk; zipper-interacting protein kinase Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq, Jul 2008]
9201 Kinase CL1; CLICK1; DCAMKL1; DCDC3A; DCLK; doublecortin and CaM kinase-like 1; doublecortin domain-containing protein 3A; doublecortin-like and CAM kinase-like 1; doublecortin-like kinase 1; serine/threonine-protein kinase DCLK1 This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splici