Entrez Gene ID Official Symbol Species Alias Names Background
null Pathways Assays CDC25A2; CDC25A2-CAG isoform; M-phase inducer phosphatase 1; cell division cycle 25 homolog A (S. cerevisiae); cell division cycle 25 homolog A (S. pombe); cell division cycle 25A; dual specificity phosphatase CDC25A CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]