CDH1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of CDH1. The page also collects GeneMedi's different modalities and formats products for CDH1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the CDH1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
Target ID | GM-T08919 |
Target Name | CDH1 |
Gene ID | 999,12550,83502,704387,442858,101095391,100066844 |
Gene Symbol and Synonyms | Arc-1,BCDS1,Cadherin-1,CD324,CDH1,CDHE,E-cad,ECAD,L-CAM,LCAM,Um,UVO,Uvomorulin |
Uniprot Accession | P12830,Q9R0T4,F1PAA9 |
Uniprot Entry Name | CADH1_HUMAN,CADH1_RAT,CADH1_CANLF |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Breast Cancer, Type 2 diabetes mellitus, Diabetic Nephropathy, Congenital occlusion of ureteropelvic junction, Gastric cancer |
Gene Ensembl | ENSG00000039068 |
Target Classification | N/A |
Pre-made anti-CDH1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-CDH1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-CDH1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-CDH1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Multi-species CADH1/ CDH1/ Arc-1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CDH1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
CDH1 VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made CDH1 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMLV000571 | human CDH1 Lentivirus plasmid | NM_004360 | Human | Lentivirus plasmid | Detail |
pGMAD000168 | human CDH1 Adenovirus plasmid | NM_004360 | Human | Adenovirus plasmid | Detail |
vGMAD000168 | human CDH1 Adenovirus particle | NM_004360 | Human | Adenovirus particle | Detail |
vGMLV000571 | human CDH1 Lentivirus particle | NM_004360 | Human | Lentivirus particle | Detail |
pGMLV000156 | mouse Cdh1 Lentivirus plasmid | NM_009864.3 | Mouse | Lentivirus plasmid | Detail |
vGMLV000156 | mouse Cdh1 Lentivirus particle | NM_009864.3 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.