Diagnostic antibodies and antigens for companion animal disease testing

Genemedi developed the antigen and antibody to detect the various disease of companion animals including dogs, cat, rabbit and so on. Detecting the quantity of marker proteins from different samples may benefit from ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

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Non infectious
Serum amyloid A Canine relaxin Cystatin C (CysC) Progesterone (Prog) C-Reactive Protein Relaxin (RLN) Canine IgG Feline IgG Canine pancreatic lipase Canine hemoglobin Pancreatic elastase (PE-1) N-terminal prohormone of brain natriuretic peptide (NT-proBNP) feline pancreatic lipase Feline AGP Canine AGP Cat/Feline lactoferrin Dog/Canine lactoferrin Alpha-1-microglobulin (A1M) Angiotensin Converting Enzyme 2 (ACE2/hFc) Angiotensin Converting Enzyme 2 (ACE2/His) acrosome protein (ACRV1) adrenocorticotropic hormone (ACTH) AD-associated neuaronal thread protein (AD7c-NTP) Adiponectin (ADPN) Alpha-fetoprotein (AFP) Angiotensin (AI) albumin protein (albumin) Anti-Mullerian hormone (AMH) atrial natriuretic peptide (ANP) Apolipoprotein A (ApoA) Apolipoprotein E (ApoE) aquaporin-4 (AQP4) beta-amyloid 38 (Aβ38) beta-amyloid 40 (Aβ40) beta-amyloid 42 (Aβ42) Beta-2 microglobulin (B2M) B-type natriuretic peptide (BNP) cancer antigen 125 (CA-125) Cancer antigen 15-3 (CA15-3) Carbohydrate antigen 19-9 (CA199) Carbohydrate Antigen 50 (CA50) Cancer Antigen 72-4 (CA-724) Calcitonin (Calcitonin) Calmodulin cystathionine-β-synthase enzyme (CBL) cystathionine-β-synthase carcinoembryonic antigen (CEA) collagen type IV (cIV) Creatine Kinase MB (CK-MB) C-type natriuretic peptide (CNP) Copeptin C-peptide (C-Peptide) C-Reactive Protein (CRP) Cardiac troponin I (cTnI) cardiac troponin T (cTnT) soluble fragment of cytokeratin-19 (CYFRA21-1) D dimer (D-Dimer) Digoxigenin (Dig) Ferritin (FER) Fetal fibronectin (fFN) Fibrinogen (FIB) follicle stimulating hormone (FSH) Gastrin (G100) Growth differentiation factor-15 (GDF-15) Glial fibrillary acid protein (GFAP) Hyaluronic acid binding protein (HABP) Haptoglobin Heparin-binding protein (HBP) epididymis protein 4 (HE4) epidermal growth factor (hEGF) hemoglobin epidermal growth factor receptor 2 (HER2) Heart-type Fatty Acid-Binding Protein (H-FABP) Heat shock proteins 90-alpha (HSP90α) Interferon gamma (IFNγ) Interleukin 6 (IL-6) Insulin (Ins) laminins (LN) Monocyte chemoattractant protein-1 (MCP-1/CCL2) matrix metalloproteinase-3 (MMP3) myelin oligodendrocyte glycoprotein (MOG) Myeloperoxidase (MPO) Myoglobin (Myo) neurogranin protein (neurogranin) neurofilament light chain (NFL) Neutrophil gelatinase-associated lipocalin (NGAL) N-terminal midfragment of Osteocalcin (N-MID OC) Neuron specific enolase (NSE) Prealbumin (PA) procalcitonin (PCT) pepsinogen I  (PG I) Pepsinogen II (PG II) Procollagen III N-terminal peptide (PIIINP) amino-terminal propeptide (PINP) Protein induced by vitamin K absence-II (PIVKA-Ⅱ) recombinant placental growth factor-1 (PLGF-1) Pregnancy Specific Protein B Pregnancy-associated glycoprotein 1 pro B-type natriuretic peptide (proBNP) Gastrin-releasing peptide (ProGRP) Proinsulin (Proinsulin) Prostate-specific antigen (PSA) Phospho-tau181 (p-tau181) Phospho-tau202 and 205 (p-tau202 and 205) Phospho-tau212 and 214 (p-tau212 and 214) Phospho-tau217 (p-tau217) Phospho-tau231 (p-tau231) Phospho-tau413 (p-tau413) Phospho-tau422 (p-tau422) parathyroid hormone (PTH) relaxin Calprotectin (S100-A8) Calprotectin heavy chain (S100-A9) S100 proteins (S100B) S-adenosylhomocysteine (AdoHcy) hydrolase squamous cell carcinoma antigen (SCC Ag) soluble vascular endothelial growth factor receptor-1 (sFlt-1) Staphylococcus protein A (SPA) Spirochaeta soluble ST2 (sST2) soluble fragment of triggering receptor expressed on myeloid cells 2 (sTREM2) tau proteins (Tau) Thyroglobulin (TG) Matrix Metalloproteinase Inhibitor-1 (TIMP-1) Thymidine Kinase 1 (TK1) tumor necrosis factor alpha (TNFα) Thyroid peroxidase (TPO) thioredoxin reductase (TrxR) Thyroid Stimulating Hormone (TSH) vitamin D binding protein (VDBP) Vascular Endothelial Growth Factor (VEGF) Visinin-like protein 1 (VLP-1) Chitinase-3-like protein 1 (CHI3L1/YKL-40) alpha defensin 1 (α-defensin 1) alpha defensin 5 (α-defensin 5) Alpha-synuclein (α-synuclein) β-isomerized C-terminal telopeptides (β-CTx)

About companion animal disease testing

The companion animals such as dogs and cats are susceptible to many diseases including personnel illnesses and infection. Infectious diseases are transmitted by contact with infected dogs or cats or wildlife. Disease causing agents (pathogens) include parasites, viruses, bacteria, fungi, and protozoa. Hundreds of these infectious pathogens have the potential to be transmitted between dogs, cats and other animals; however, only a subset of these commonly causes problems.

Additionally, some of these pathogens can be spread between companion animals and people (termed “zoonotic”), causing illness in people adding additional concerns. When a case of infectious disease is suspected, it is important to get a diagnosis quickly and identify susceptible animals that might have been exposed. The diagnosis of companion animal disease is complex because the spectrum of clinical signs and clinicopathological abnormalities is broad and often nonspecific.

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