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Anti-DXd/Exatecan monoclonal antibody (mAb)
MSDSUtilizing our specific Anti-DXd/Exatecan Monoclonal Antibody can target and quantify, accurately, DXd/Exatecan related ADCs effectively as our product facilitates large-scale pharmacokinetic evaluations. Essential to the understanding of ADCs’ life cycle, such assessment offers a valuable insight of their absorption, distribution, and elimination phases to help optimize use of ADC-based therapies.
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Information
Order information
| Catalog No. | Product Name | Size | Price(In USD) | Shipping & Handling Fee |
|---|---|---|---|---|
| GTU-Bios-DXd-Ab-1 | Anti-DXd/Exatecan human monoclonal antibody (mAb) | 1mg | 1690 | 360 |
| GTU-Bios-DXd-Ab-2 | Anti-DXd/Exatecan mouse monoclonal antibody (mAb) | 1mg | 1690 | 360 |
| GTU-Bios-DXd-Ab-3 | Anti-DXd/Exatecan mouse monoclonal antibody (mAb) | 1mg | 1690 | 360 |
| GTU-Bios-DXd-Ab-1 | Anti-DXd/Exatecan human monoclonal antibody (mAb) | 100μg | 310 | 60 |
| GTU-Bios-DXd-Ab-2 | Anti-DXd/Exatecan mouse monoclonal antibody (mAb) | 100μg | 310 | 60 |
| GTU-Bios-DXd-Ab-3 | Anti-DXd/Exatecan mouse monoclonal antibody (mAb) | 100μg | 310 | 60 |
Size: 1mg | 10mg | 100mg
Description
Anti-DXd/Exatecan human monoclonal antibody (mAb)
| Cat No. | GTU-Bios-DXd-Ab-1 |
| Product Name | Anti-DXd/Exatecan human monoclonal antibody (mAb) |
| Target | Deruxtecan (DXd) / Exatecan |
| Expression platform | mammalian cell |
| Isotypes | Human IgG1 |
| Bioactivity validation | Deruxtecan (DXd) / Exatecan binding, Competitive immunoassay validation (Competitive ELISA) in Deruxtecan (DXd) / Exatecan level test. |
| Tag | hFc |
| Products description | Anti-Deruxtecan (DXd) / Exatecan monoclonal antibody is expressed from mammalian cell. |
| Species | Human |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for DXd & Exatecan payload of Antibody-drug Conjugate (ADC). |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Anti-DXd/Exatecan mouse monoclonal antibody (mAb)
| Cat No. | GTU-Bios-DXd-Ab-2, GTU-Bios-DXd-Ab-3 |
| Product Name | Anti-DXd/Exatecan mouse monoclonal antibody (mAb) |
| Target | Deruxtecan (DXd) / Exatecan |
| Expression platform | mammalian cell |
| Isotypes | Mouse IgG |
| Bioactivity validation | Deruxtecan (DXd) / Exatecan binding, Competitive immunoassay validation (Competitive ELISA) in Deruxtecan (DXd) / Exatecan level test. |
| Tag | mFc |
| Products description | Anti-Deruxtecan (DXd) / Exatecan) mouse monoclonal antibody (mAb) is expressed from mammalian cell. |
| Species | Mouse |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for DXd & Exatecan payload of Antibody-drug Conjugate (ADC). |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Validation Data
- Figure 1: Specific Binding with DXd
- Figure 2: minimal impact on pharmacokinetic (PK) studies
Figure 1. GeneMedi's GTU-Bios-DXd-Ab: Specific Binding with DXd, Not Binding with SN38.
GeneMedi's GTU-Bios-DXd-Ab exhibits specific binding to DXd-based ADCs, demonstrating its effectiveness. Moreover, it does not bind to ADCs conjugated with SN38, underscoring GeneMedi's commitment to producing highly selective antibodies.
Figure 2. GTU-Bios-DXd-Ab has minimal impact on pharmacokinetic (PK) studies involving humans and monkeys.
GTU-Bios-DXd-Ab demonstrates minimal influence in PK studies with humans and monkeys, rendering it appropriate for application in these experiments.
Click to get more Data / Case study about the product.
Associated products
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|---|---|---|---|
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