Anti-MMAE (Monomethyl auristatin E) monoclonal antibody (mAb)

Order information

Catalog No.	Product Name	Size	Price(In USD)
GTU-Bios-Auristatin-Ab-02-1	Anti-MMAE (Monomethyl auristatin E) human monoclonal antibody (mAb)	1mg	1690
GTU-Bios-Auristatin-Ab-02-2	Anti-MMAE (Monomethyl auristatin E) mouse monoclonal antibody (mAb)	1mg	1690
GTU-Bios-Auristatin-Ab-02-3	Anti-MMAE (Monomethyl auristatin E) mouse monoclonal antibody (mAb)	1mg	1690

Size： 1mg | 10mg | 100mg

Description

Anti-MMAE (Monomethyl auristatin E) human monoclonal antibody (mAb)

Cat No.	GTU-Bios-Auristatin-Ab-02-1
Product Name	Anti-MMAE (Monomethyl auristatin E) human monoclonal antibody (mAb)
Target	Monomethyl auristatin E (MMAE)
Expression platform	mammalian cell
Isotypes	Human IgG1
Bioactivity validation	Monomethyl auristatin E (MMAE) binding, Competitive immunoassay validation (Competitive ELISA) in Monomethyl auristatin E (MMAE) level test.
Tag	hFc
Products description	Anti-Monomethyl auristatin E (MMAE) monoclonal antibody is expressed from mammalian cell.
Species	Human
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for MMAE payload of Antibody-drug Conjugate (ADC).
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-MMAE (Monomethyl auristatin E) mouse monoclonal antibody (mAb)

Cat No.	GTU-Bios-Auristatin-Ab-02-2, GTU-Bios-Auristatin-Ab-02-3
Product Name	Anti-MMAE (Monomethyl auristatin E) mouse monoclonal antibody (mAb)
Target	Monomethyl auristatin E (MMAE)
Expression platform	mammalian cell
Isotypes	Mouse IgG
Bioactivity validation	Monomethyl auristatin E (MMAE) binding, Competitive immunoassay validation (Competitive ELISA) in Monomethyl auristatin E (MMAE) level test.
Tag	mFc
Products description	Anti-Monomethyl auristatin E (MMAE)) mouse monoclonal antibody (mAb) is expressed from mammalian cell.
Species	Mouse
Purity	Purity: ≥95% (SDS-PAGE)
Application	Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for MMAE payload of Antibody-drug Conjugate (ADC).
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Validation Data

Figure 1. GMP-Bios-MMAE-Ab-2 and GMP-Bios-MMAE-Ab-3 have been actively bound with the ADC (PTM-1 MMAE).

Figure 1 demonstrates the efficacy of GeneMedi's GMP-Bios-MMAE-Ab-2 and GMP-Bios-MMAE-Ab-3 in actively binding with the ADC (PTM-1 MMAE). This underscores GeneMedi's commitment to producing high-quality antibodies tailored for effective conjugation with MMAE-based ADCs.

The robust binding displayed in the figure highlights GeneMedi's expertise in developing antibodies optimized for targeted drug delivery, a critical aspect in the field of antibody-drug conjugates.

Figure 2. The GMP-Bios-MMAE-Ab-2 has been actively bound with the ADC (PTM-1 MMAF). While GMP-Bios-MMAE-Ab-3 has not been bound with the ADC with MMAF.

In Figure 2, the specificity of GeneMedi's antibodies is showcased as GMP-Bios-MMAE-Ab-2 successfully binds with the ADC (PTM-1 MMAF), while GMP-Bios-MMAE-Ab-3 remains unbound. This specificity is pivotal in ensuring precise targeting of MMAE-containing ADCs, enhancing their therapeutic efficacy while minimizing off-target effects.

GeneMedi's ability to tailor antibodies to selectively bind with distinct drug payloads exemplifies their proficiency in antibody engineering, offering researchers reliable tools for precision medicine applications.

Figure 3. GMP-Bios-MMAE-Ab-2 and GMP-Bios-MMAE-Ab-3 have not been bound with the ADC conjugated with DXD.

Figure 3 illustrates another aspect of GeneMedi's antibody specificity, revealing that neither GMP-Bios-MMAE-Ab-2 nor GMP-Bios-MMAE-Ab-3 binds with the ADC conjugated with DXD. This data underscores GeneMedi's dedication to producing antibodies with high selectivity, ensuring minimal interference with undesired payloads.

By providing antibodies that exhibit minimal cross-reactivity, GeneMedi empowers researchers with precise tools for designing and optimizing ADCs for targeted cancer therapy, ultimately advancing the forefront of biomedical research and clinical applications.

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