Anti-MMAE/MMAF monoclonal antibody(mAb)

Our Anti-MMAE/MMAF Monoclonal Antibody has been created to fit the needs of those working on the pharmacokinetics of ADCs, as well as for understanding the nature of MMAE and MMAF. It provides a clear picture of the doses of MMAE/MMAF conjugated-ADCs and allow for proper analysis of the pharmacokinetic characteristics of the compound such as the absorption, distribution, metabolism and excretion profiles. This antibody is invaluable to those investigators dedicated to optimizing ADC treatments.

Check the Technical Information


MMAE

Order information


Product Name Catalog No. Size Price(In USD)
Anti-MMAE/MMAF human monoclonal antibody(mAb) GTU-Bios-Auristatin-Ab-01-1 1mg 1690
Anti-MMAE/MMAF mouse monoclonal antibody(mAb) GTU-Bios-Auristatin-Ab-01-2 1mg 1690
Anti-MMAE/MMAF mouse monoclonal antibody(mAb) GTU-Bios-Auristatin-Ab-01-3 1mg 1690

Size: 1mg | 10mg | 100mg




Description


Anti-MMAE/MMAF human monoclonal antibody(mAb)

Cat No. GTU-Bios-Auristatin-Ab-01-1
Product Name Anti-MMAE/MMAF human monoclonal antibody(mAb)
Target MMAE(monomethyl auristatin E)/MMAF(monomethyl auristatin F)
Expression platform mammalian cell
Isotypes Human IgG1
Bioactivity validation MMAE/MMAF binding, Competitive immunoassay validation (Competitive ELISA) in MMAE/MMAF level test.
Tag hFc
Products description Anti-MMAE/MMAF monoclonal antibody is expressed from mammalian cell.
Species Human
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for MMAE/MMAF payload of Antibody-drug Conjugate (ADC).
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-MMAE/MMAF mouse monoclonal antibody(mAb)

Cat No. GTU-Bios-Auristatin-Ab-01-2, GTU-Bios-Auristatin-Ab-01-3
Product Name Anti-MMAE/MMAF mouse monoclonal antibody(mAb)
Target MMAE(monomethyl auristatin E)/MMAF(monomethyl auristatin F)
Expression platform mammalian cell
Isotypes Mouse IgG
Bioactivity validation MMAE/MMAF binding, Competitive immunoassay validation (Competitive ELISA) in MMAE/MMAF level test.
Tag mFc
Products description Anti-MMAE/MMAF mouse monoclonal antibody (mAb) is expressed from mammalian cell.
Species Mouse
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for MMAE/MMAF payload of Antibody-drug Conjugate (ADC).
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Validation Data


    • Figure 1: Coating PTM-1 MMAE
    • Figure 2: Coating PTM-1 MMAF
    • Figure 3: Coating PTM-1 DXD
    • Figure 4: Pharmacokinetic (PK) studies
    Picture loading failed.

    Figure 1. GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 have been actively bound with the ADC (PTM-1 MMAE).

    Figure 1 demonstrates the efficacy of GeneMedi's GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 in actively binding with the ADC (PTM-1 MMAE). This underscores GeneMedi's commitment to producing high-quality antibodies tailored for effective conjugation with MMAE-based ADCs.

    The robust binding displayed in the figure highlights GeneMedi's expertise in developing antibodies optimized for targeted drug delivery, a critical aspect in the field of antibody-drug conjugates.

    Picture loading failed.

    Figure 2. The GTU-Bios-Auristatin-Ab-01-2 has been actively bound with the ADC (PTM-1 MMAF). While GTU-Bios-Auristatin-Ab-02-2 has not been bound with the ADC with MMAF.

    In Figure 2, the specificity of GeneMedi's antibodies is showcased as GTU-Bios-Auristatin-Ab-01-2 successfully binds with the ADC (PTM-1 MMAF), while GTU-Bios-Auristatin-Ab-02-2 remains unbound. This specificity is pivotal in ensuring precise targeting of MMAE-containing ADCs, enhancing their therapeutic efficacy while minimizing off-target effects.

    GeneMedi's ability to tailor antibodies to selectively bind with distinct drug payloads exemplifies their proficiency in antibody engineering, offering researchers reliable tools for precision medicine applications.

    Picture loading failed.

    Figure 3. GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 have not been bound with the ADC conjugated with DXD.

    Figure 3 illustrates another aspect of GeneMedi's antibody specificity, revealing that neither GTU-Bios-Auristatin-Ab-01-2 nor GTU-Bios-Auristatin-Ab-02-2 binds with the ADC conjugated with DXD. This data underscores GeneMedi's dedication to producing antibodies with high selectivity, ensuring minimal interference with undesired payloads.

    By providing antibodies that exhibit minimal cross-reactivity, GeneMedi empowers researchers with precise tools for designing and optimizing ADCs for targeted cancer therapy, ultimately advancing the forefront of biomedical research and clinical applications.

    Picture loading failed.

    Figure 4: GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 can be used in pharmacokinetic (PK) studies involving humans and monkeys

    GTU-Bios-Auristatin-Ab-01-2 has minimal impact in human and monkey PK studies and can be considered negligible. GTU-Bios-Auristatin-Ab-02-2 has even less impact than GTU-Bios-Auristatin-Ab-01-2 in these PK studies. Both GTU-Bios-Auristatin-Ab-01-2 and GTU-Bios-Auristatin-Ab-02-2 are suitable for use in human and monkey PK experiments.

    Click to get more Data / Case study about the product.



    Associated products


    Cat No. Product Name Technical Information Products Information
    GTU-Bios-Maytansinoids-Ab Anti-DM1/DM4 monoclonal antibody(mAb) More Details
    GTU-Bios-Auristatin-Ab-01 Anti-MMAE/MMAF monoclonal antibody(mAb) More Details
    GTU-Bios-Auristatin-Ab-02 Anti-MMAE (Specific) monoclonal antibody(mAb) More Details
    GTU-Bios-DXd-Ab Anti-DXd&Exatecan monoclonal antibody(mAb) More Details
    GTU-Bios-CPT-Ab Anti-CPTmonoclonal antibody(mAb) More Details
    GTU-Bios-Eribulin-Ab Anti-Eribulin monoclonal antibody(mAb) More Details
    GTU-Bios-Exatecan-Ab Anti-Exatecan monoclonal antibody(mAb) More Details
    GTU-Bios-SN-38-Ab Anti-SN-38 monoclonal antibody(mAb) More Details
    GTU-Bios-Budesonide-Ab Anti-Budesonide monoclonal antibody (mAb) More Details
    GTU-Bios-MTX-Ab Anti-MTX monoclonal antibody(mAb) More Details
    GTU-Bios-PBD-Ab Anti-PBD monoclonal antibody(mAb) More Details
    GTU-Bios-PNU-159682-Ab Anti-PNU-159682 monoclonal antibody(mAb) More Details
    GTU-Bios-Amanitin-Ab Anti-Amanitin monoclonal antibody(mAb) More Details
    GTU-Bios-Calicheamicin-Ab Anti-Calicheamicin monoclonal antibody(mAb) More Details
    GTU-Bios-Doxorubicin-Ab Anti-Doxorubicin monoclonal antibody (mAb) More Details
    GTU-Bios-Duocarmycin-Ab Anti-Duocarmycin monoclonal antibody (mAb) More Details

    Technical Resource


    The Knowledge base of Antibody-drug Conjugate (ADC)
  • The Landscape of ADC: Production, MOA, FDA approved-antibodies, and Functional assay
  • What is antibody-drug conjugate (ADC)?
  • Antibody-drug conjugate (ADC) in clinical application (Approved/BLA, phaseI/II/III)
  • Main elements of antibody-drug conjugate (ADC): Antibodies and their targets
  • Main elements of antibody-drug conjugate (ADC): Linker (structure and mechanism)
  • Main elements of antibody-drug conjugate (ADC): Toxins/Payloads (Classification and function)
  • Toxins/Payloads (Classification and function) of Microtubule destroying drug
  • Toxins/Payloads (Classification and function) of DNA damage drugs
  • Toxins/Payloads (Classification and function) of Innovative drugs
  • Biological coupling technology Chemical based specific in situ antibody modification
  • Endogenous coupling of amino acids and Disulfide re bridging strategy
  • Glycan coupling
  • Site specific biological coupling of engineered antibodies and Enzymatic method
  • Biological coupling with engineered unnatural amino acids
  • Review for ADC production, quality control and functional assay
  • Product data of ADC
  • Comments


    Geoffrey James 2024-04-03 18:59:28
    The product that I recently had the privilege of using from GeneMedi is the Anti-MMAE/MMAF monoclonal antibody. In our pharmacokinetic studies it provided accurate and reproducible results which in turn strengthened our ADC investigation. Definitely worth it for the money and provides great results.
    Maria Steves 2024-02-09 19:03:07
    I have recently employed the Anti-MMAE/MMAF monoclonal antibody from GeneMedi and every time I am more than satisfied with the outcomes. This product showed very high specificity and binding which helped immensely the ADC projects that we had in house. The batch-to-batch variation is rather low, which allows for the results produced to be rather stable and comparable across multiple experiments. Technical support from GeneMedi was also quite useful, offering comprehensive information and efficient communication with the customers. I would like to highly encourage anyone engaged in the research of oncology drug development to use this product.
    Valerie Carter 2023-09-22 19:05:39
    The Anti-MMAE/MMAF monoclonal antibody from GeneMedi in comparison with other products differs mostly by higher stability. To this end, the data clearly demonstrates that it offers a stable performance profile over time, which of course has a positive impact on the reliability and replicability of the research results obtained.

    Leave a comment