GeneMedi's SOLIDEX™-ISOEx Immunocytes Cell Isolation Immunomagnetic Beads

• Introduction
• Product list
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• Validation data

Introduction and Applications of SOLIDEX™-ISOEx Immunocytes Cell Isolation Immunomagnetic Beads

GeneMedi SOLIDEX™-ISOEx Immunocytes Cell Isolation Immunomagnetic Beads provide cutting-edge magnetic separation solutions for comprehensive immune cell isolation. The platform covers essential immune cell types including NK cells, B cells, Pan T cells, CD4+ T cells, and CD8+ T cells. Additionally, GeneMedi also offers extensive selection capabilities targeting critical cellular markers such as CD66b+ cells, CD34+ cells, CD14+ cells, TCR alpha-beta (abT)+ cells, CD138+ cells, CD45RA+ cells, CD45+ cells, CD16+ cells, and CD25+ cells, ensuring ultra-high purity isolation while maintaining cellular integrity throughout the separation process.

GeneMedi SOLIDEX™-ISOEx features three distinct isolation methodologies to meet diverse research requirements. The Positive Selection platform enables direct capture of specific cell populations using antibodies against well-defined surface markers, ideal for applications requiring precisely characterized cellular subsets. The Negative Selection system provides superior preservation of native cellular function through magnetic depletion of non-target cells, yielding completely untouched and functionally pristine target populations. For specific depletion needs, the Depletion strategy allows precise removal of defined cell types from complex mixtures. All three SOLIDEX™-ISOEx platforms are engineered to deliver outstanding performance, providing researchers with flexible solutions that balance high purity requirements with optimal cellular function preservation for both research and clinical applications.

Our magnetic bead-based isolation systems support two flexible labeling strategies to accommodate diverse experimental needs:

Direct Magnetic Activated Cell Separation (Direct MACS)	Indirect Magnetic Activated Cell Separation (Indirect MACS)
Principle: Antibodies are directly conjugated to magnetic beads, allowing for immediate cell capture and isolation. Advantages: Ideal for fast, one-step separation of target cells with minimal handling.	Principle: Antibodies are biotinylated, enabling secondary capture via streptavidin (SA)-coupled magnetic beads. Advantages: Provides enhanced flexibility, particularly when multiplex labeling or sequential isolation is required.

Column-Based Magnetic Separation	Column-Free Magnetic Separation
Principle: This method utilizes a column packed with a ferromagnetic matrix placed within a strong external magnetic field. Cells labeled with 50nm magnetic bead-conjugated antibodies are passed through the column. The powerful magnetic field gradient generated by the matrix traps the labeled target cells, while unlabeled cells flow through. After washing, the isolated target cells are eluted by removing the column from the magnet. Advantages: The key advantage is the high purity of the isolated cell population. The column system creates a high-gradient magnetic field that ensures efficient capture of cells, even those weakly labeled or present in low numbers. This makes it ideal for applications requiring the highest possible purity.	Principle: This streamlined method uses specialized magnetic beads that can be separated directly in standard tubes or other vessels. After incubating the cell sample with the bead-conjugated antibodies, the tube is placed on a suitable magnet (e.g., a magnetic stand). The labeled target cells are attracted to the wall of the tube by the magnetic force, while the unlabeled cells remain in the suspension. The supernatant containing undesired cells is simply decanted or pipetted away. Advantages:The primary advantages are speed, simplicity, and scalability. It is a faster process that does not require specialized columns, making it perfect for quick experiments, processing large sample volumes, or simultaneous isolation of multiple samples. This format is highly suitable for routine isolation and high-throughput workflows.

Key Features & Benefits

1. High-purity isolation of immune and stem cell populations (e.g., T cells, B cells, NK cells, monocytes).

2. Optimized for reproducibility in cell therapy, immunology research, and functional studies.

3. Available in two formats (direct magnetic bead conjugation or biotin-SA magnetic bead coupling) for protocol versatility.

Available Antibody-Magnetic Bead Conjugates

GeneMedi provides a comprehensive selection of monoclonal antibody (mAb) conjugates, including:

1. Anti-Human CD3E, CD4, CD8, CD14, CD19, CD45, CD34, CD138

2. Anti-Human NCAM1 (CD56), TCR alpha-beta (abT), CD45RA

These products are designed to streamline cell separation workflows, ensuring high recovery rates and sample integrity for advanced research applications.

GeneMedi's SOLIDEX™-ISOEx Immunocytes Cell Isolation Immunomagnetic Beads - Product list

Our magnetic bead-based cell isolation portfolio now offers six tailored configurations, combining three critical parameters to match diverse experimental needs: Labeling Type (Direct/Indirect) x Bead Type (Non-releasable/Releasable) x Format (Column/Column-free).

Validation Data