GeneMedi SOLIDEX® Immune Cell Solution
GeneMedi offers a comprehensive one-stop solution covering cell separation, flow cytometry analysis, and CAR-T cell therapy development, empowering precision medicine research and clinical translation.
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About GeneMedi SOLIDEX®
SOLIDEX® is GeneMedi's proprietary comprehensive solution for immune cell solution, dedicated to providing efficient and reliable tools for cell separation and analysis. This series includes the SOLIDEX®-ISOEx nanoscale non-destructive cell separation product matrix, SOLIDEX®-CDEx multi-color hypersensitive flow cytometry antibodies, and SOLIDEX®-TAGEx CAR multimodal analysis tools.
SOLIDEX® Immune Cell Solution Detail
ISOEx Cell Isolation Nanobeads
Separation Strategies & Formats
Separation Strategy
- Positive Selection: Directly captures target cells for high-purity, high-recovery enrichment.
- Negative Selection (Untouched): Depletes unwanted cells, leaving target cells unlabeled and native—ideal for downstream culture, expansion, and functional assays.
- Depletion: Selectively removes specific lineages or unwanted populations for downstream analysis.
Magnetic Format
- Column-Based: Uses high-gradient magnetic columns (compatible with M/L Columns & MagSuite) for high purity and recovery.
- Column-Free: Fast, tube-based separation with reduced mechanical shear stress, compatible with the Magnetic Sorter series.
Product Portfolio
Target Cells: NK, B, Pan-T, CD4+ T, CD8+ T, CD14+ monocytes, CD34+, TCR αβ+, CD138+, CD45RA+, CD45+, CD16+, CD25+, CD66b+, etc.
Compatible Samples: Fresh/frozen PBMCs, whole blood/buffy coat (post density gradient) and leukapheresis.
Target Cells: Mouse Pan-T, CD4+ T, Naïve CD4+ T, F4/80+ Macrophages, etc.
Compatible Samples: Fresh single-cell suspensions from mouse spleen, lymph nodes, bone marrow, and other tissues.
Target Cells: Customizable for rare, non-standard, or exploratory targets via custom antibody/ligand conjugation.
Compatible Samples: PBMCs, whole blood, leukapheresis material, and tissue single-cell suspensions.
Key Features: Versatile second-step nanobeads with strong magnetic response, low non-specific binding, and compatibility with column and column-free workflows.
CAR Constructs: G4S Linker, Whitlow (218) Linker, VHH Framework, and other universal CAR elements.
Compatible Samples: Cell suspensions across CAR engineering workflows.
Key Features: Specifically engineered for high-purity, high-recovery CAR+ cell isolation in cell therapy R&D and manufacturing QC.
Platform Features: High-gradient magnetic design; fully compatible with industry-standard columns and beads; scalable from manual benchtop processing to high-throughput automation.
CDEx Flow Cytometry Antibodies
Function: Multiplexed, high-sensitivity analysis of immune cell phenotypes at the single-cell level.
Product Portfolio:
- PE/APC/FITC-Conjugated Antibodies: Targeting CD3E, CD4, CD7, CD8, CD14, CD15, CD16, CD19, CD25, CD32, CD33, CD34, CD36, CD41, CD45, NCAM1 (CD56), CD123, CD138, TCR alpha-beta (abT), TCR Gamma Delta (γδ), CD45RA.
- Naked Antibodies: Support custom labeling (e.g., biotin, fluorescent dyes).
Technical Advantages:
- Exceptional sensitivity and specificity for complex samples like PBMCs.
TAGEx CAR-Analytical Tools
Companion Detection Tools:
- CAR-Specific Antibodies: Targeting scFv (e.g., FMC63), VHH, G4S, G3S, Whitlow (218) nanobodies, hinge/transmembrane domains, and intracellular signaling motifs.
- Quality Control: Simulated sample testing and reduced background signals (outperforms Company C).
Lentiviral Vector Services:
- Target Proteins: CD19 (leukemia), BCMA (multiple myeloma), Her2 (breast cancer), GPC3 (hepatocellular carcinoma), etc.
- Key Features: High transduction efficiency, low genotoxicity, and support for multi-gene payloads (≤6.5 kb).
Service Workflow:
- Lentivirus packaging → CAR-T cell engineering → Functional validation → Preclinical/clinical trial support
End-to-End Coverage
From cell isolation → phenotypic analysis → gene modification → functional validation.
Customization
Tailored solutions for antibody labeling, vector design, and target optimization.
Synergy
Immunomagnetic bead-based purification enhances flow cytometry accuracy; lentiviral systems ensure efficient CAR-T production.
Applications
Oncology immunotherapy, Autoimmune disease research, Rare disease modeling, CAR-T clinical pipeline development
