GeneMedi SOLIDEX® Immune Cell Solution
GeneMedi offers a comprehensive one-stop solution covering cell separation, flow cytometry analysis, and CAR-T cell therapy development, empowering precision medicine research and clinical translation.
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About GeneMedi SOLIDEX®
SOLIDEX® is GeneMedi's proprietary comprehensive solution for immune cell solution, dedicated to providing efficient and reliable tools for cell separation and analysis. This series includes the SOLIDEX®-ISOEx nanoscale non-destructive cell separation product matrix, SOLIDEX®-CDEx multi-color hypersensitive flow cytometry antibodies, and SOLIDEX®-TAGEx CAR multimodal analysis tools.
SOLIDEX® Immune Cell Solution Detail
ISOEx Cell Isolation Nanobeads
Function: High-purity enrichment of specific immune cells or stem cells for downstream experiments.
Product Highlights:
- Optimized antibodies targeting CD3, CD4, CD8, CD14, CD19, CD34, NK (CD56), monocytes (CD14), and more.
Core Technologies:
| Category | Type | Description | Advantages | Disadvantages |
|---|---|---|---|---|
| Labeling Method | Direct cell isolation | Antibodies directly conjugated to magnetic beads | Fastest method (single-step) High specificity Simple protocol | Limited flexibility High capacity to antibodies |
| Indirect cell isolation | Uses biotinylated secondary capture (reusable beads) | Antibody flexibility Cost-effective Signal amplification possible | Longer protocol Potential for higher background Additional step required | |
| Bead Type | Releasable | Allow competitive elution | Better for sensitive applications Simple workflow | More expensive beads May interfere with some tasks |
| Non-releasable | Form irreversible bonds (Streptavidin beads) | Ideal for negative selection More economical | Permanent bead attachment | |
| Format | Column-based | Uses magnetic columns with 50nm beads | Highest purity | Requires columns Slower processing Higher cost |
| Column-free | Uses larger beads with external magnets | Fast processing (<15 min) No column costs | Slightly lower purity Less suitable for automation |
CDEx Flow Cytometry Antibodies
Function: Multiplexed, high-sensitivity analysis of immune cell phenotypes at the single-cell level.
Product Portfolio:
- PE/APC/FITC-Conjugated Antibodies: Targeting CD3E, CD4, CD8, CD14, CD19, NCAM1 (CD56), TCR αβ, and others.
- Naked Antibodies: Support custom labeling (e.g., biotin, fluorescent dyes).
Technical Advantages:
- Exceptional sensitivity and specificity for complex samples like PBMCs.
TAGEx CAR-Analytical Tools
Companion Detection Tools:
- CAR-Specific Antibodies: Targeting scFv (e.g., FMC63), VHH, G4S nanobodies, hinge/transmembrane domains, and intracellular signaling motifs.
- Quality Control: Simulated sample testing and reduced background signals (outperforms Company C).
Lentiviral Vector Services:
- Target Proteins: CD19 (leukemia), BCMA (multiple myeloma), Her2 (breast cancer), GPC3 (hepatocellular carcinoma), etc.
- Key Features: High transduction efficiency, low genotoxicity, and support for multi-gene payloads (≤6.5 kb).
Service Workflow:
- Lentivirus packaging → CAR-T cell engineering → Functional validation → Preclinical/clinical trial support
End-to-End Coverage
From cell isolation → phenotypic analysis → gene modification → functional validation.
Customization
Tailored solutions for antibody labeling, vector design, and target optimization.
Synergy
Immunomagnetic bead-based purification enhances flow cytometry accuracy; lentiviral systems ensure efficient CAR-T production.
Applications
Oncology immunotherapy, Autoimmune disease research, Rare disease modeling, CAR-T clinical pipeline development
