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AAV Helper Plasmid - Introduction

GeneMedi offer ready-to-use AAV helper plasmid that is optimized for recombinant Adeno-associated virus (rAAV) packaging, production, and manufacturing within the adenovirus (Adv) helper virus-free system.

The GeneMedi AAV helper plasmid vector contains a mini adenovirus genome that is necessary for recombinant AAV (rAAV) packaging regardless of AAV Rep and Cap genes1,2. The genes consisting mini adenovirus genome in the AAV helper plasmid are described as below:
1. The adenovirus E4 gene for AAV DNA replication
2. The adenovirus E2a gene and adenovirus VA RNA (virus-associated RNA ) genes: enhancing AAV mRNA stability, facilitating AAV gene translation, especially for AAV Capsids transcripts.

Map and sequence of AAV Helper Plasmid

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Order AAV Helper Plasmid

Product Name Organization Type Price(In USD) Qty (Quantity) Sum(In USD)
AAV Helper Plasmid
Size: 5ug
Academic 504
AAV Helper Plasmid
Size: 5ug
Industry R&D
AAV Helper Plasmid
Size: 5ug
Manufacturing company
Shipping Cost: 169.00


1. Matsushita, T. et al. Adeno-associated virus vectors can be efficiently produced without helper virus. Gene Therapy 5, 938-945, doi:10.1038/sj.gt.3300680 (1998). Download article PDF
2. Xiao, X., Li, J. & Samulski, R. J. Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus. JOURNAL OF VIROLOGY 72, 2224-2232 (1998). Download article PDF

AAV Rep-Cap Plasmid

AAV1 Rep-Cap Plasmid

AAV2 Rep-Cap Plasmid

AAV2 variant (Y444F) Rep-Cap plasmid

AAV2 variant (Y272F, Y444F, Y500F, Y730F) Rep-Cap plasmid

AAV2 variant (Y444F, Y730F, Y500F, Y272F, Y704F, Y252F) Rep-Cap plasmid

AAV2 variant(AAV2.7m8) Rep-Cap plasmid

AAV5 Rep-Cap Plasmid

AAV-6 Rep-Cap Plasmid

AAV8 Rep-Cap Plasmid

AAV8-1m Rep-Cap plasmid

AAV8-2m Rep-Cap plasmid

AAV8 variant (Y733F, Y447F, Y275) Rep-Cap plasmid

AAV9 Rep-Cap Plasmid

AAV-Rh.10 Rep-Cap Plasmid

AAV-Dj Rep-Cap Plasmid

AAV-Retro (Retrograde) Rep-Cap plasmid

AAV9-PHP.B Rep-Cap plasmid

AAV9-PHP.eB Rep-Cap plasmid

AAV9-PHP.S Rep-Cap plasmid

AAV9-BR1 Rep-Cap plasmid

AAV9-2i8 Rep-Cap plasmid

AAV9-SIG Rep-Cap plasmid

AAV9-VEC Rep-Cap plasmid