Anti-G4S monoclonal antibody (mAb)

The Anti-G4S monoclonal antibody (mAb) for CAR-T cell preparation implies the utilization of G4S linker-based antibody in the course of lentivirus packaging. This approach improves the avidity and selectivity of CAR-T cells – T cells that have been genetically modified to bear a chimeric antigen receptor (CAR) for cancer cells – by enabling the stable integration of the CAR gene. This method enhances the technique of producing CAR-T cells to enable enhanced targeting of cancers for treatment.

Check the application of G4S in CAR-T Cell Preparation-Lentivirus Packaging


pdfMSDSpdfCOApdfDatasheet

Order information


Catalog No. Product Name Size Price(In USD)
GMLS-Tag003-Ab01 Anti-G4S human monoclonal antibody (mAb) 1mg 1690
GMLS-Tag003-Ab02 Anti-G4S mouse monoclonal antibody (mAb) 1mg 1690
GMLS-Tag003-Ab03 Anti-G4S mouse monoclonal antibody (mAb) 1mg 1690

Size： 1mg | 10mg | 100mg


Description


Anti-G4S human monoclonal antibody (mAb)

Cat No. GMLS-Tag003-Ab01
Product Name Anti-G4S human monoclonal antibody (mAb)
Target G4S
Expression platform mammalian cell
Isotypes Human IgG1
Bioactivity validation G4S binding, Competitive immunoassay validation (Competitive ELISA) in G4S level test.
Tag hFc
Products description Anti-G4S monoclonal antibody is expressed from mammalian cell.
Species Human
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for G4S payload of Antibody-drug Conjugate (ADC).
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Anti-G4S mouse monoclonal antibody (mAb)

Cat No. GMLS-Tag003-Ab02, GMLS-Tag003-Ab03
Product Name Anti-G4S mouse monoclonal antibody (mAb)
Target G4S
Expression platform mammalian cell
Isotypes Mouse IgG
Bioactivity validation G4S binding, Competitive immunoassay validation (Competitive ELISA) in G4S level test.
Tag mFc
Products description Anti-G4S mouse monoclonal antibody (mAb) is expressed from mammalian cell.
Species Mouse
Purity Purity: ≥95% (SDS-PAGE)
Application Competitive immunoassay validation (Competitive ELISA) and other Immunoassay, PK & PD assay for G4S payload of Antibody-drug Conjugate (ADC).
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Validation Data


    FMC64 and G4S Linker antibody validation

    Figure 1. The GTU-ADA-FMC63-Ab01 and GMLS-Tag003-Ab-1 are validated to detect CAR-NK cells.

    G4S Linker antibody validation

    Figure 2. For detecting CAR-T cells, GeneMedi’s GMLS-Tag003-Ab-1 detection background is lower, and the detection results are closer to specific antigen detection, compared to Company C.


    Click to get more Data / Case study about the product.



    Associated products

    Category Cat No. Products Name
    CAR Detection Antibody GMLS-Tag003-Ab01 Anti-G4S monoclonal antibody (mAb)
    CAR Detection Antibody GTU-ADA-FMC63-Ab01~06 Anti-FMC63 monoclonal antibody (mAb)
    CAR Detection Antibody GMLS-Tag002-Ab01 Anti-VHH monoclonal antibody (mAb)