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PurProX® AAVPure Affinity Resin — The Engine for Industrial Manufacturing
PurProX® Pre-packed Columns (0.5mL/1mL/5mL) serve as the critical link between R&D and scale-up.
Pre-filled with the exact same AAVPure Affinity Media used in bulk manufacturing, these columns are available in both U1 and U2 versions. Their "Plug-and-Play" design allows researchers to bypass tedious packing procedures, enabling direct connection to FPLC systems (e.g., ÄKTA) for serotype-specific parameter screening and small-scale vector production.
· Serotype Specificity Options:
- AAVPure-U1 (Broad-Spectrum): Delivers broad, high-efficiency binding for AAV2, AAV5, AAV6, AAV8, AAV-DJ, and AAV-7m8.
- AAVPure-U2 (AAV9 Specialized): Engineered with a specialized ligand for high-affinity capture of AAV9 and its variants, specifically resolving the low-binding efficiency often seen with conventional resins.
· High-efficiency and reproducibility
· Specificity for intact AAV particle
· >3e14 VP/mL resin
· Lower cost
COAKey Technical Specifications for PurProX® AAVPure Affinity Resin
- Mass Transfer Optimization: Large-pore architecture maintains exceptional Dynamic Binding Capacity (DBC) even under high-velocity industrial flow conditions.
- Mechanical Stability: Rigid polymer matrix withstands backpressures exceeding 1MPa, perfectly suited for large-scale columns and high-throughput systems.
- High Efficiency: Optimized ligand kinetics ensure consistent recovery rates >90%, maximizing batch yield.
Order information for PurProX® AAVPure Affinity Resin U1 & U2
| Product Type | Catalog No. | Product Name | Size | Price(In USD) |
|---|---|---|---|---|
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-1-10ml | PurProX® AAVPure Affinity Resin-1 | 10mL | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-1-25ml | PurProX® AAVPure Affinity Resin-1 | 25mL | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-1-50ml | PurProX® AAVPure Affinity Resin-1 | 50mL | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-1-250ml | PurProX® AAVPure Affinity Resin-1 | 250mL | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-1-1L | PurProX® AAVPure Affinity Resin-1 | 1L | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-1-5L | PurProX® AAVPure Affinity Resin-1 | 5L | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-2-10ml | PurProX® AAVPure Affinity Resin-2 | 10mL | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-2-25ml | PurProX® AAVPure Affinity Resin-2 | 25mL | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-2-50ml | PurProX® AAVPure Affinity Resin-2 | 50mL | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-2-250ml | PurProX® AAVPure Affinity Resin-2 | 250mL | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-2-1L | PurProX® AAVPure Affinity Resin-2 | 1L | |
| AAV Affinity Resin | GMV-PurProX-AAVPure-U-2-5L | PurProX® AAVPure Affinity Resin-2 | 5L |
Related Products of PurProX® AAVPure Affinity Resin
| Product Type | Catalog No. | Product Name | Size | Price(In USD) |
|---|---|---|---|---|
| Pre-packed Column | GMV-PurProX-AAVPure-U-1-P1ml | PurProX® AAVPure Pre-packed Column-1 | 1mL | |
| Pre-packed Column | GMV-PurProX-AAVPure-U-2-P1ml | PurProX® AAVPure Pre-packed Column-2 | 1mL | |
| Pre-packed Column | GMV-PurProX-AAVPure-U-1-P5ml | PurProX® AAVPure Pre-packed Column-1 | 5mL | |
| Pre-packed Column | GMV-PurProX-AAVPure-U-2-P5ml | PurProX® AAVPure Pre-packed Column-2 | 5mL |
Description
| Catalog number | GMV-PurProX-AAVPure-U-1;GMV-PurProX-AAVPure-U-2 |
| Product name | PurProX® AAVPure Affinity Resin |
| Support matrix | Polymer resin |
| Immobilized ligand | VHH |
| Serotype affinity | GMV-PurProX-AAVPure-U-1: Tested-Binding- AAV2, AAV5, AAV6, AAV8, AAV7m8, AAV-DJ; GMV-PurProX-AAVPure-U-2: Tested-Binding- AAV9 |
| Binding capacity | ~3E+14 vp per mL resin |
| Shipping solvent | 2% Benzyl Alcohol |
| Average particle size | 50 µm |
| Recommended flow rate | ≥3-minute residence time |
| Mechanical resistance | 10bar (1Mpa) |
| pH Range (all ligands) | 2-10 |
| Operating temperature | RT |
| Storage instruction | Do not freeze |
Validation Data of PurProX® AAVPure Affinity Resin
PurProX® AAVPure Affinity Resin-1 for AAV Serotype 2, 5, 6,8, DJ, and 7m8 Purification
The silver staining of purified AAVs by PurProX® AAVPure Affinity Resin-1 (GMV-PurProX-AAVPure-U-1). Company T‘s Resin is used as the control.
PurProX® AAVPure Affinity Resin-2 Designed for AAV9 Purification
The silver staining of purified AAV9 by PurProX® AAVPure Affinity Resin-2 (GMV-PurProX-AAVPure-U-2). Company T‘s Resin is used as the control.
Frequently Asked Questions (FAQ)
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Q1: Is the resin available in a pre-packed column format?
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A1: Yes. GeneMedi offers PurProX™ AAVPure Pre-packed Columns, which are pre-filled with the exact same high-performance affinity media used in bulk manufacturing. They are available in both U1 and U2 versions, with sizes of 1 mL and 5 mL.
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Q2: What is the specificity of the resin?
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A2: The resin has a high degree of specificity for intact AAV particles, enabling effective binding of target viral particles while excluding impurities.
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Q3: Is the resin cost-effective?
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A3: Yes. The resin is cost-effective, providing a more competitive price while ensuring high performance, helping to reduce the production costs of gene therapy drugs.
