Discover the latest insights, protocols, and breakthroughs in Gene Therapy, Biologics, and Diagnostics from GeneMedi experts.
1.0 Introduction: The Quest for the Perfect Cell Population For life science researchers, the success of a downstream experiment often hinges on the quality of the starting material. The constant need to isolate pure, viable, and functional cell pop...
1.0 Introduction: The Quest for the Perfect Cell Population For life science researchers, the success of a downstream experiment often hinges on the quality of the starting material. The constant need to isolate pure, viable, and functional cell pop...
1.0 Introduction: The Quest for the Perfect Cell Population For life science researchers, the success of a downstream experiment often hinges on the quality of the starting material. The constant need to isolate pure, viable, and functional cell pop...
For life science researchers, the success of a downstream experiment often hinges on the quality of the starting material. The constant need to isolate pure, viable, and functional cell populations is a foundational challenge. Whether for cell t...
Adeno-associated virus (AAV) has emerged as the leading platform for in vivo gene delivery. However, achieving high titers (>1E13 vg/mL) while maintaining high capsid fullness remains a significant challenge for many laboratories. In this g...
Transducing primary neurons can be challenging due to their fragility. In this case study, we demonstrate the superior performance of the engineered capsid AAV-PHP.eB. Experiment Setup Cell Type: Rat Primary Cortical Neurons (D...
CRISPR-Cas9 has revolutionized biology. But how does it actually work? Think of it as a "find and replace" tool for DNA. The Components The system consists of two main parts: Cas9 Enzyme: The "molecular scissors" that cut t...
The U.S. Food and Drug Administration (FDA) today approved Hemgenix-Next, an adeno-associated virus (AAV) vector-based gene therapy for the treatment of adults with Hemophilia B. A One-Time Treatment Unlike current standard-of-care trea...
Adeno-associated virus (AAV) manufacturing is a critical bottleneck in gene therapy. High-titer and high-purity production requires rigorous optimization of the upstream transfection process. In this study, we compare the two most widely us...
