Diagnostics antibodies and antigens for ruminant disease testing

Ruminants continue to be important in their traditional role in agricultural. In addition, ruminants play a vital role in the economy of poor, deprived, backward classes, and landless labors of developing countries. To make this small ruminant-based economy viable and sustainable, development of techniques for early and accurate diagnosis holds prime importance.

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Non infectious
Bovine Serum amyloid A Bovine Pregnancy Specific Protein B Cow Pregnancy-associated glycoprotein 1 IFN-γ bovine Calmodulin Bovine Spirochaeta Bovine Haptoglobin prion Bovine lactoferrin Bovine AGP Alpha-1-microglobulin (A1M) Angiotensin Converting Enzyme 2 (ACE2/hFc) Angiotensin Converting Enzyme 2 (ACE2/His) acrosome protein (ACRV1) adrenocorticotropic hormone (ACTH) AD-associated neuaronal thread protein (AD7c-NTP) Adiponectin (ADPN) Alpha-fetoprotein (AFP) Angiotensin (AI) albumin protein (albumin) Anti-Mullerian hormone (AMH) atrial natriuretic peptide (ANP) Apolipoprotein A (ApoA) Apolipoprotein E (ApoE) aquaporin-4 (AQP4) beta-amyloid 38 (Aβ38) beta-amyloid 40 (Aβ40) beta-amyloid 42 (Aβ42) Beta-2 microglobulin (B2M) B-type natriuretic peptide (BNP) cancer antigen 125 (CA-125) Cancer antigen 15-3 (CA15-3) Carbohydrate antigen 19-9 (CA199) Carbohydrate Antigen 50 (CA50) Cancer Antigen 72-4 (CA-724) Calcitonin (Calcitonin) cystathionine-β-synthase enzyme (CBL) cystathionine-β-synthase carcinoembryonic antigen (CEA) collagen type IV (cIV) Creatine Kinase MB (CK-MB) C-type natriuretic peptide (CNP) Copeptin C-peptide (C-Peptide) C-Reactive Protein (CRP) Cardiac troponin I (cTnI) cardiac troponin T (cTnT) soluble fragment of cytokeratin-19 (CYFRA21-1) Cystatin C (CYSC) D dimer (D-Dimer) Digoxigenin (Dig) Ferritin (FER) Fetal fibronectin (fFN) Fibrinogen (FIB) follicle stimulating hormone (FSH) Gastrin (G100) Growth differentiation factor-15 (GDF-15) Glial fibrillary acid protein (GFAP) Hyaluronic acid binding protein (HABP) Heparin-binding protein (HBP) epididymis protein 4 (HE4) epidermal growth factor (hEGF) hemoglobin epidermal growth factor receptor 2 (HER2) Heart-type Fatty Acid-Binding Protein (H-FABP) Heat shock proteins 90-alpha (HSP90α) Interferon gamma (IFNγ) Interleukin 6 (IL-6) Insulin (Ins) laminins (LN) Monocyte chemoattractant protein-1 (MCP-1/CCL2) matrix metalloproteinase-3 (MMP3) myelin oligodendrocyte glycoprotein (MOG) Myeloperoxidase (MPO) Myoglobin (Myo) neurogranin protein (neurogranin) neurofilament light chain (NFL) Neutrophil gelatinase-associated lipocalin (NGAL) N-terminal midfragment of Osteocalcin (N-MID OC) Neuron specific enolase (NSE) N-terminal prohormone of brain natriuretic peptide (NT-proBNP) Prealbumin (PA) Pancreatic elastase (PE-1) pancreatic lipase procalcitonin (PCT) pepsinogen I  (PG I) Pepsinogen II (PG II) Procollagen III N-terminal peptide (PIIINP) amino-terminal propeptide (PINP) Protein induced by vitamin K absence-II (PIVKA-Ⅱ) recombinant placental growth factor-1 (PLGF-1) pro B-type natriuretic peptide (proBNP) Gastrin-releasing peptide (ProGRP) Gastrin-releasing peptide (ProGRP) Proinsulin (Proinsulin) Prostate-specific antigen (PSA) Phospho-tau181 (p-tau181) Phospho-tau202 and 205 (p-tau202 and 205) Phospho-tau212 and 214 (p-tau212 and 214) Phospho-tau217 (p-tau217) Phospho-tau231 (p-tau231) Phospho-tau413 (p-tau413) Phospho-tau422 (p-tau422) parathyroid hormone (PTH) relaxin Calprotectin (S100-A8) Calprotectin heavy chain (S100-A9) S100 proteins (S100B) S-adenosylhomocysteine (AdoHcy) hydrolase squamous cell carcinoma antigen (SCC Ag) soluble vascular endothelial growth factor receptor-1 (sFlt-1) Staphylococcus protein A (SPA) soluble ST2 (sST2) soluble fragment of triggering receptor expressed on myeloid cells 2 (sTREM2) tau proteins (Tau) Thyroglobulin (TG) Matrix Metalloproteinase Inhibitor-1 (TIMP-1) Thymidine Kinase 1 (TK1) tumor necrosis factor alpha (TNFα) Thyroid peroxidase (TPO) thioredoxin reductase (TrxR) Thyroid Stimulating Hormone (TSH) vitamin D binding protein (VDBP) Vascular Endothelial Growth Factor (VEGF) Visinin-like protein 1 (VLP-1) Chitinase-3-like protein 1 (CHI3L1/YKL-40) alpha defensin 1 (α-defensin 1) alpha defensin 5 (α-defensin 5) Alpha-synuclein (α-synuclein) β-isomerized C-terminal telopeptides (β-CTx)

About Ruminant disease testing

However, ruminants suffer from numerous diseases, namely, fowl cholera, atrophic rhinitis, transmissible spongiform encephalopathies (TSEs), abortion, akabane disease, bluetongue disease, borna disease, borrelia theileri infection, botulism, bovine amyloidosis, bovine besnoitiosis, bovine Parainfluenza-3 Virus (BPI3) infection, bovine respiratory syncytial virus infection, bovine spongiform encephalopathy, bovine viral diarrhea, calf enteritis, enzootic pneumonia complex, winter dysentery, campylobacteriosis, caprine arthritis encephalitis, caprine pleuropneumonia, chlamydiosis, traveler's diarrhea, chronic wasting disease, congenital diseases, contagious agalactia, contagious bovine pleuropneumonia, cystic hydatidosis, cysticercosis, enzootic bovine leukosis, fascioliasis, gastroenteritis, glanders, hemorrhagic septicemia, hormone disorders, hypodermiasis, immune dysfunction, leptospirosis, lumpy skin disease, maedi visna virus infection, mastitis, arthritis, pneumonia, nonbacterial diarrheic disease, paratuberculosis, paratuberculosis, PESTE des petits ruminants, pneumonia, prion associated diseases, Q fever, reproductive disease, respiratory disease, rift valley fever, rinderpest or cattle plague, rotaviral diarrhea, salmonellosis, schmallenberg disease, septicemia, septicemic colibacillosis, sexually transmitted infectious disease, trichomoniasis, tuberculosis/leprosy and so on.

In such scenario, the rapid and specific detection of antigens and antibodies of these pathogens are developed by Genemedi. Detecting the quantity of marker proteins from different samples may benefit from ELISA, Lateral flow immunoassay (LFIA), colloidal gold immunochromatographic assay, Chemiluminescent immunoassay (CLIA), turbidimetric inhibition immuno assay (TINIA), immunonephelometry and POCT.

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