SOLIDEX™ TCR alpha-beta (abT)+ Cell Isolation Solution
Introduction of SOLIDEX™ TCR alpha-beta (abT)+ Cell Isolation Solution
TCRαβ+ Cells refer primarily to T cells that express αβ T cell receptors (TCR), including CD4+ helper T cells and CD8+ cytotoxic T cells. These cells make up more than 95% of the peripheral blood T cells and are a core component of the adaptive immune system.
TCRαβ is a heterodimer receptor on the surface of T cells, composed of α and β chains, specifically expressed on conventional T cells but not on γδ T cells or non-T cells, providing highly specific antigen recognition. GeneMedi offers TCR alpha-beta (abT)+ cell magnetic beads for the positive selection or depletion of TCRαβ+ cells to meet various research and therapeutic needs.
Isolation method of SOLIDEX™ TCR alpha-beta (abT)+ Cell Isolation Solution
- Positive Selection
- Depletion
Research Applications:
Positive selection is used to isolate TCRαβ+ T cells, allowing further analysis of white blood cell concentration, cell viability, and immune cell composition (including B cells). This process helps deepen the understanding of the roles and interactions of different immune cell populations in the immune system.
| Cat.No | Product Name | Products Information |
|---|---|---|
| GM-Tg-hg-MP2610-iso-nanoIMB | Human TCR alpha-beta (abT) Nano-mag Beads (Column-Based) | Details |
| GM-Tg-hg-MP2610-iso-nanoIMB-CF | Human TCR alpha-beta (abT) Nano-mag Beads (Column-Free) | Details |
| GM-Tg-hg-MP2610-iso-rel-kit | Indirect Releasable Human TCR alpha-beta (abT)+ Cell Isolation Kit (Column-Based) | Details |
| GM-Tg-hg-MP2610-iso-rel-kit-CF | Indirect Releasable Human TCR alpha-beta (abT)+ Cell Isolation Kit (Column-Free) | Details |
| GM-Tg-hg-MP2610-iso-kit | Indirect Human TCR alpha-beta (abT)+ Cell Isolation Kit (Column-Based) | Details |
| GM-Tg-hg-MP2610-iso-kit-CF | Indirect Human TCR alpha-beta (abT)+ Cell Isolation Kit (Column-Free) | Details |
Clinical Applications:
In hematopoietic stem cell transplantation (HSCT), studies show that removing αβ T lymphocytes from peripheral blood stem cells (PBSC), while retaining all other cell populations, supports allogeneic transplantation by providing immune modulation and reducing transplant rejection responses. Additionally, TCRαβ/CD19 depletion in hematopoietic stem cell transplantation has shown promising applications in treating hematologic malignancies. Finally, a clinical trial studied the effect of TCRαβ+ and CD19+ cell depletion on enhancing γδ T cell cytotoxicity against leukemia cells in the presence of ZOLE (Zoledronic acid), with results showing that T cell reconstitution played a positive regulatory role during treatment.
| Cat.No | Product Name | Products Information |
|---|---|---|
| GM-Tg-hg-MP2610-dep-nanoIMB | Human TCR alpha-beta (abT)+ Cell Depletion Nano-mag Beads (Column-Based) | Details |
| GM-Tg-hg-MP2610-dep-kit | Indirect Human TCR alpha-beta (abT)+ Cell Depletion Kit (Column-Based) | Details |
