SOLIDEX®-ISOEx MagSuite：Column-based Magnetic Separators and Accessories
The SOLIDEX®-ISOEx Magnetic Separator is specifically designed for the SOLIDEX®-ISOEx Cell Isolation Kit & Nanobeads (Column-based). Equipped with high-performance built-in permanent magnets, it generates a high-gradient magnetic field within the SOLIDEX®-ISOEx Column to effectively capture nanobead-labeled target cells. It is suitable for applications including positive selection, negative selection, and cell depletion, supporting scalable cell sorting to achieve high-throughput processing.
SOLIDEX®-ISOEx Separators equipped with Columns.
Why Choose the SOLIDEX®-ISOEx Magnetic Separator?
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High-Efficiency Capture: Achieves optimal purity and recovery rates even with minimal nanobead labeling.
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Rapid and Gentle: Preserves cell viability, making it highly suitable for downstream applications such as flow cytometry analysis and immune cell preparation.
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Broad Compatibility: Beyond its seamless integration with the SOLIDEX®-ISOEx Column and Cell Isolation Kit & Nanobeads (Column-based), it boasts full compatibility with mainstream magnetic beads and sorting equipment available on the market.
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Flexible Throughput Options: Available in single-channel (MX1, LX1) and multi-channel (MX8, LX4) models, catering to varied throughput demands ranging from single-sample handling up to 8-channel parallel processing.
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User-Friendly Operation: Its standard benchtop design allows for flexible assembly with a universal stand, while the magnetic attachment mechanism ensures rapid and secure installation and removal.
| Cat.No | Product Name | Description | Products Link |
|---|---|---|---|
| GMP-ISOEx-Mag-MX1 | SOLIDEX®-ISOEx MX1 Magnetic Separator | SOLIDEX®-ISOEx MX1 Magnetic Separator is developed for single-channel magnetic cell isolations in combination with SOLIDEX®-ISOEx Column-Based Nanobeads and compatible columns, which can realize the rapid and gentle isolation of labeled cells by inducing a high-gradient magnetic field and ensure the stability and activity maintenance of cells. | Details |
| GMP-ISOEx-Mag-MX8 | SOLIDEX®-ISOEx MX8 Magnetic Separator | SOLIDEX®-ISOEx MX8 Magnetic Separator is developed for eight-channel and high-throughput magnetic cell isolations allowing up to eight simultaneous processes with SOLIDEX®-ISOEx Column-Based Nanobeads and columns, which can realize the rapid and gentle parallel isolation of labeled cells by inducing a high-gradient magnetic field and ensure the stability and activity maintenance of cells. | Details |
| GMP-ISOEx-Mag-LX1 | SOLIDEX®-ISOEx LX1 Magnetic Separator | SOLIDEX®-ISOEx LX1 Magnetic Separator is developed for single-channel magnetic cell isolations of larger sample volumes in combination with SOLIDEX®-ISOEx Column-Based Nanobeads and compatible columns, which can realize the rapid and gentle isolation of labeled cells by inducing a high-gradient magnetic field and ensure the stability and activity maintenance of cells. | Details |
| GMP-ISOEx-Mag-LX4 | SOLIDEX®-ISOEx LX4 Magnetic Separator | SOLIDEX®-ISOEx LX4 Magnetic Separator is developed for four-channel and medium-to-large scale magnetic cell isolations allowing up to four simultaneous processes with SOLIDEX®-ISOEx Column-Based Nanobeads and columns, which can realize the rapid and gentle parallel isolation of labeled cells by inducing a high-gradient magnetic field and ensure the stability and activity maintenance of cells. | Details |
| GMP-ISOEx-Mag-Stand-1 | SOLIDEX®-ISOEx Stand | SOLIDEX®-ISOEx Stand is developed for stable and convenient mounting of multiple SOLIDEX®-ISOEx Column-Based magnetic separators (MX1, MX8, LX1, LX4), which can realize efficient parallel processing workflows and ensure reliable operation during cell isolation. | Details |
| GMP-ISOEx-Mag-Stand-2 | SOLIDEX®-ISOEx Mini Stand | SOLIDEX®-ISOEx Mini Stand is developed for compact benchtop mounting of one to two SOLIDEX®-ISOEx Column-Based magnetic separators, which can realize space-saving parallel processing and ensure stable, reliable operation during small-scale cell isolation. | Details |
| GMP-ISOEx-Column-M | SOLIDEX®-ISOEx M Column | SOLIDEX®-ISOEx M Column is developed for the isolation of cells labeled with superparamagnetic nanobeads, which can realize the rapid and gentle isolation of flowing cells and ensure the stability and activity maintenance of cells. | Details |
| GMP-ISOEx-Column-L | SOLIDEX®-ISOEx L Column | SOLIDEX®-ISOEx L Column is developed for the isolation of cells labeled with superparamagnetic nanobeads, which can realize the rapid and gentle isolation of flowing cells and ensure the stability and activity maintenance of cells. | Details |
FAQ
Q1: What is the core difference between the SOLIDEX®-ISOEx MX and LX series Magnetic Separators?
The primary difference lies in their column compatibility and corresponding cell processing capacity.
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SOLIDEX®-ISOEx MX Series (MX1 / MX8): Specifically designed for the SOLIDEX®-ISOEx M Column, generating a high-gradient magnetic field optimized for smaller volumes. Suitable for small-scale samples up to 2×10⁸ total cells.
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SOLIDEX®-ISOEx LX Series (LX1 / LX4): Engineered for the SOLIDEX®-ISOEx L Column, providing a uniform strong magnetic field covering a larger column volume. Ideal for large-scale samples up to 2×10⁹ total cells.
Please ensure you strictly match the separator series with the corresponding column size (M or L) to guarantee optimal isolation purity and recovery.
Q2: What factors should be considered when choosing between single-channel (MX1/LX1) and multi-channel (MX8/LX4) separators?
The selection depends primarily on your laboratory's sample throughput requirements and workflow efficiency.
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Single-channel models (MX1 / LX1): Ideal for basic experimental setups involving individual or low-volume sample processing.
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Multi-channel models (MX8 / LX4): Designed for high-throughput parallel processing. The MX8 accommodates up to 8 M Columns simultaneously, while the LX4 holds up to 4 L Columns. This configuration significantly reduces batch-to-batch variation and dramatically enhances efficiency for multi-sample screening.
Q3: What is the primary function of the SOLIDEX®-ISOEx Stand? Can it accommodate multiple separators simultaneously?
The SOLIDEX®-ISOEx Stand is the core base component that provides high-stability support for all the aforementioned separators. Because cell isolation requires precise buffer application and elution, the weighted design ensures absolute stability on the workbench.
Furthermore, it features high modular compatibility. A single stand can securely hold one large/multi-channel unit (like an LX4 or MX8), or, via adapters, simultaneously accommodate multiple single-channel units (such as several MX1 or LX1 units), offering flexible spatial layouts for complex workflows.
Q4: Will the magnetic field strength of the separators degrade over time?
No. The entire SOLIDEX®-ISOEx Magnetic Separator lineup utilizes industrial-grade, ultra-strong permanent magnets. Under standard laboratory operating (15°C - 35°C) and storage conditions, the magnetic induction strength maintains long-term stability without degradation, requiring zero maintenance over its lifespan.
Q5: What are the guidelines for routine cleaning and maintenance of the equipment?
Please adhere to the following maintenance protocols:
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No Autoclaving: Extreme temperatures will cause irreversible demagnetization and structural deformation of the casing.
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Surface Cleaning: Regularly wipe the exterior with 70% ethanol or a 1% sodium hypochlorite solution for disinfection. Follow with a wipe-down using sterile water or a mild detergent, and allow it to air dry.
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Avoid Corrosion: Do not submerge the units in liquid for extended periods, and avoid using strong acidic or alkaline solvents.
Q6: What is the main difference between the SOLIDEX®-ISOEx M Column and the SOLIDEX®-ISOEx L Column? How should I choose?
The primary difference lies in their maximum cell loading capacity.
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SOLIDEX®-ISOEx M Column: Designed for small-scale isolations (up to 2×108 total cells and 2×107 labeled target cells).
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SOLIDEX®-ISOEx L Column: Designed for large-scale isolations (up to 2×109 total cells and 2×108 labeled target cells).
Select the column based on your starting cell number and expected target cell yield.
Q7: What isolation strategies are compatible with these columns?
When used with the SOLIDEX®-ISOEx Cell Isolation Kit & Nanobeads, both columns fully support:
Positive Selection
Negative Selection
Depletion
The high-gradient magnetic field ensures optimal retention of labeled cells while allowing unlabeled cells to flow through smoothly.
Q8: Can the SOLIDEX®-ISOEx columns be washed and reused?
No, they are intended for single use only.
Reusing columns poses a high risk of cross-contamination. Additionally, repeated washing alters the column's internal matrix, significantly compromising purity, recovery rate, and flow rate—leading to unreliable results.
Q9: Are the columns sterile? Do I need to sterilize them before use?
Yes, the columns are strictly sterilized and individually packaged. They are ready to use directly in a laminar flow hood or biosafety cabinet without additional sterilization.
However, always equilibrate (rinse) the column with the recommended buffer according to the protocol before applying your cell suspension.
Q10: What should I do if the column flow rate slows down or gets clogged?
Clogging is usually caused by cell clumps or exceeding capacity. We recommend these preventative measures:
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Filtration: Always pass your cell suspension through a 30 µm or 70 µm cell strainer before loading.
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Nuclease Treatment: If viscosity is high due to free DNA from dead cells, treat the suspension with DNase I.
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Capacity Check: Ensure neither the total cell number nor the labeled target cell number exceeds the column's specified limits.
Q11: Are these columns compatible with standard magnetic separators currently on the market?
Yes. The external dimensions of both the M and L Columns are highly compatible with industry standards. They fit perfectly into mainstream magnetic separators of corresponding sizes, allowing seamless integration into your existing workflow without purchasing new equipment.
