SOLIDEX™ CD45RA+ Cell Isolation Solution
Introduction of SOLIDEX™ CD45RA+ Cell Isolation Solution
CD45RA+ cells primarily refer to naive T cells and certain other leukocytes (e.g., subsets of B cells and NK cells), widely present in peripheral blood, bone marrow, and lymphoid tissues. CD45RA, an isoform of the CD45 protein, is specifically expressed on the surface of naive T cells and other non-activated leukocytes, distinguishing them from memory T cells (which express CD45RO) with high specificity. GeneMedi provides CD45RA magnetic beads for positive selection or depletion of CD45RA+ cells to meet diverse research and therapeutic needs.
Isolation method of SOLIDEX™ CD45RA+ Cell Isolation Solution
- Positive Selection
- Depletion
Research Applications:
Positive selection of CD45RA+ cells is widely used in various research applications, particularly in studies of cytokine expression and receptor signaling pathways, enabling in-depth exploration of naive T cell functions in immune responses.
| Cat.No | Product Name | Products Information |
|---|---|---|
| GM-Tg-hg-T43115-8-iso-nanoIMB | SOLIDEX™-ISOEx Human CD45RA Isolation Nanobeads (Column-based) | Details |
| GM-Tg-hg-T43115-8-iso-nanoIMB-CF | SOLIDEX™-ISOEx Human CD45RA Isolation Nanobeads (Column-free) | Details |
| GM-Tg-hg-T43115-8-iso-rel-kit | SOLIDEX™-ISOEx Indirect Releasable Human CD45RA+ Cell Isolation Kit (Column-based) | Details |
| GM-Tg-hg-T43115-8-iso-rel-kit-CF | SOLIDEX™-ISOEx Indirect Releasable Human CD45RA+ Cell Isolation Kit (Column-free) | Details |
| GM-Tg-hg-T43115-8-iso-kit | SOLIDEX™-ISOEx Indirect Human CD45RA+ Cell Isolation Kit (Column-based) | Details |
| GM-Tg-hg-T43115-8-iso-kit-CF | SOLIDEX™-ISOEx Indirect Human CD45RA+ Cell Isolation Kit (Column-free) | Details |
Research Applications:
Depletion of CD45RA+ cells is commonly used to isolate CD45RO+ cells from pre-sorted CD4 or CD8 T cells, facilitating studies of memory T cell functions and immunological characteristics to further understand their role in immune responses.
Clinical Applications:
Depletion of CD45RA+ cells from peripheral blood stem cell (PBSC) products significantly enriches CD4+ and CD8+ central memory T cells, which can proliferate and produce effector cytokines in response to opportunistic pathogens, enhancing immune reconstitution and effectively reducing CD8-mediated allogeneic reactivity. Studies also demonstrate that CD45RA-depleted donor lymphocyte infusion combined with post-transplant cyclophosphamide effectively improves clinical outcomes.
| Cat.No | Product Name | Products Information |
|---|---|---|
| GM-Tg-hg-T43115-8-dep-nanoIMB | SOLIDEX™-ISOEx Human CD45RA+ Cell Depletion Nanobeads (Column-based) | Details |
| GM-Tg-hg-T43115-8-dep-kit | SOLIDEX™-ISOEx Indirect Human CD45RA+ Cell Depletion Kit (Column-based) | Details |
