SOLIDEX™ CD34+ Cell Isolation Solution
Introduction of SOLIDEX™ CD34+ Cell Isolation Solution
CD34+ cells primarily refer to hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs), which are found in the bone marrow, umbilical cord blood, and peripheral blood. CD34+ cells possess self-renewal and multipotent differentiation capabilities, playing a critical role in hematopoietic function reconstitution and immune system repair.
CD34 is a transmembrane glycoprotein specifically expressed on the surface of hematopoietic stem and progenitor cells, widely used as a marker for these cells. GeneMedi offers CD34 magnetic beads for positive selection or depletion of CD34+ cells, catering to various research and therapeutic needs.
Isolation method of SOLIDEX™ CD34+ Cell Isolation Solution
- Positive Selection
- Depletion
Research Applications:
Positive selection of CD34+ cells for in vitro culture is used to analyze the effects of various tyrosine kinase inhibitors on downstream targets. Subsequent techniques such as Western blot, qPCR, and cell cycle analysis are employed to investigate the molecular mechanisms of these cells. Additionally, positive selection is frequently used in studies related to hematopoiesis, differentiation, colony formation, and the expression of surface markers.
Clinical Applications:
Stem cell grafts obtained through positive selection are highly purified, free from other cell populations, ensuring the safety of transplantation. In the treatment of acute myeloid leukemia (AML), transplantation of these purified CD34+ stem cells can effectively alleviate the disease. Moreover, this technique is also applied in the treatment of patients with non-union fractures, showing promising clinical prospects. Another clinical study demonstrated that CD34+ enriched grafts from HLA-matched related or unrelated donors have been applied in the treatment of myelodysplastic syndromes, offering new therapeutic possibilities for patients.
| Cat.No | Product Name | Products Information |
|---|---|---|
| GM-Tg-hg-T66426-iso-nanoIMB | Human CD34 Nano-mag Beads (Column-Based) | Details |
| GM-Tg-hg-T66426-iso-nanoIMB-CF | Human CD34 Nano-mag Beads (Column-Free) | Details |
| GM-Tg-hg-T66426-iso-rel-kit | Indirect Releasable Human CD34+ Cell Isolation Kit (Column-Based) | Details |
| GM-Tg-hg-T66426-iso-rel-kit-CF | Indirect Releasable Human CD34+ Cell Isolation Kit (Column-Free) | Details |
| GM-Tg-hg-T66426-iso-kit | Indirect Human CD34+ Cell Isolation Kit (Column-Based) | Details |
| GM-Tg-hg-T66426-iso-kit-CF | Indirect Human CD34+ Cell Isolation Kit (Column-Free) | Details |
Research Applications:
By removing CD34+ cells, pure populations of mature hematopoietic cells (such as T cells or B cells) can be obtained to support immunological research.
| Cat.No | Product Name | Products Information |
|---|---|---|
| GM-Tg-hg-T66426-dep-nanoIMB | Human CD34+ Cell Depletion Nano-mag Beads (Column-Based) | Details |
| GM-Tg-hg-T66426-dep-kit | Indirect Human CD34+ Cell Depletion Kit (Column-Based) | Details |
