| Cat No. |
GMLS-Tag006-Ab01-nanoIMB
|
| Product Name |
SOLIDEX®-ISOEx Anti-Whitlow (218) Linker Nanobeads (Column-Based) |
| Description |
Paramagnetic 50 nm nanobeads directly conjugated with a high-affinity monoclonal antibody specific to the Whitlow (218) linker sequence (GSTSGSGKPGSGEGSTKG) in chimeric antigen receptor (CAR) constructs. Specifically designed for the column-based, non-destructive positive selection or depletion of Whitlow-CAR-expressing cells (e.g., CAR-T, CAR-NK) from heterogeneous cell samples (such as human PBMCs). |
| Application |
CAR-T/NK Cell Isolation: High-purity positive selection of 218-linker-containing CAR cells (e.g., matching Yescarta, Breyanzi, Abecma designs) from mixed populations. Un-transduced Cell Depletion: Efficient removal of CAR-negative cells during cell manufacturing workflows. Downstream Assays: Direct compatibility with post-separation culture expansion, in vitro killing assays, or multi-color flow cytometry. |
| Component for 5E8 cells (50Tests) / 1E9 cells(100tests) / 7.5E9 cells (750tests)
|
GMLS-Tag006-Ab01-nanoIMB: SOLIDEX®-ISOEx Anti-Whitlow (218) Linker Nanobeads (Column-Based) |
| Labeling Type |
Direct |
| Bead Type |
Non-releasable |
| Format |
Column-based
|
| Key feature |
High-Gradient Column Purity: Leverages column-based magnetic fields to achieve exceptional purity and yield, even for weakly positive cell populations. Biocompatible 50 nm Nanobeads: Ultra-small 50 nm beads with excellent biocompatibility require no post-separation "de-beading," minimizing cell stress and preserving high cell viability. Universal CAR Targeting: Eliminates the need for multiple target-specific ligands, serving as a standardized tool for diverse CAR constructs. |
COA