SOLIDEX®-ISOEx Anti-Whitlow (218) Linker Nanobeads (Column-Based) (Cat No.:GMLS-Tag006-Ab01-nanoIMB)


Paramagnetic 50 nm nanobeads directly conjugated with a high-affinity monoclonal antibody specific to the Whitlow (218) linker sequence (GSTSGSGKPGSGEGSTKG) in chimeric antigen receptor (CAR) constructs. Specifically designed for the column-based, non-destructive positive selection or depletion of Whitlow-CAR-expressing cells (e.g., CAR-T, CAR-NK) from heterogeneous cell samples (such as human PBMCs).


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Order information


Catalog No. Product Name Size Price(In USD)
SOLIDEX®-ISOEx Anti-Whitlow (218) Linker Nanobeads (Column-Based)-0.5mL SOLIDEX®-ISOEx Anti-Whitlow (218) Linker Nanobeads (Column-Based) 0.5 mL
SOLIDEX®-ISOEx Anti-Whitlow (218) Linker Nanobeads (Column-Based)-1mL SOLIDEX®-ISOEx Anti-Whitlow (218) Linker Nanobeads (Column-Based) 1 mL

Description


Cat No. GMLS-Tag006-Ab01-nanoIMB
Product Name SOLIDEX®-ISOEx Anti-Whitlow (218) Linker Nanobeads (Column-Based)
Description

Paramagnetic 50 nm nanobeads directly conjugated with a high-affinity monoclonal antibody specific to the Whitlow (218) linker sequence (GSTSGSGKPGSGEGSTKG) in chimeric antigen receptor (CAR) constructs. Specifically designed for the column-based, non-destructive positive selection or depletion of Whitlow-CAR-expressing cells (e.g., CAR-T, CAR-NK) from heterogeneous cell samples (such as human PBMCs).
Application

CAR-T/NK Cell Isolation: High-purity positive selection of 218-linker-containing CAR cells (e.g., matching Yescarta, Breyanzi, Abecma designs) from mixed populations.
Un-transduced Cell Depletion: Efficient removal of CAR-negative cells during cell manufacturing workflows.
Downstream Assays: Direct compatibility with post-separation culture expansion, in vitro killing assays, or multi-color flow cytometry.
Labeling Type Direct
Bead Type Non-releasable
Format Column-based
Key feature

High-Gradient Column Purity: Leverages column-based magnetic fields to achieve exceptional purity and yield, even for weakly positive cell populations.
Biocompatible 50 nm Nanobeads: Ultra-small 50 nm beads with excellent biocompatibility require no post-separation "de-beading," minimizing cell stress and preserving high cell viability.
Universal CAR Targeting: Eliminates the need for multiple target-specific ligands, serving as a standardized tool for diverse CAR constructs.
Storage Store at 2°C-8°C

Validation Data

Efficient Isolation of Jurkat Cells Using SOLIDEX®-ISOEx Indirect Human TCR alpha-beta (abT)+ Cell Isolation Kit (Column-Based)  

Catalog No. GM-Tg-hg-MP2610-iso-kit  To evaluate the performance of GeneMedi’s SOLIDEX®-ISOEx Indirect Human TCR alpha-beta (abT)+ Cell Isolation Kit (Column-Based), Jurkat cells were mixed with 293T-GFP cells at a 1:2 ratio, followed by magnetic separation using both GeneMedi’s kit and a competitor’s (Company M’s TCRα/β T Cell Isolation Kit). The purity of isolated Jurkat cells was assessed via flow cytometry analysis. SOLIDEX®-ISOEx Indirect Human TCR alpha-beta (abT)+ Cell Isolation Kit (Column-Based) delivers superior cell isolation performance.  Figure 1. Efficient Isolation of Jurkat Cells Using SOLIDEX®-ISOEx Indirect Human TCR alpha-beta (abT)+ Cell Isolation Kit (Column-Based). The flow cytometry analysis of the purified Jurkat cells by using Company M’s TCRα/β T Cell isolation kit and SOLIDEX®-ISOEx Indirect Human TCR alpha-beta (abT)+ Cell Isolation Kit (Column-Based). 


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