Anti-CADH1/ CDH1/ Arc-1 monoclonal antibody

Anti-CADH1/ CDH1/ Arc-1 antibody for FACS & in-vivo assay

Target products collectionGo to CDH1/CDH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T08919-Ab-1/ GM-Tg-hg-T08919-Ab-2Anti-Human CDH1 monoclonal antibodyHuman
GM-Tg-rg-T08919-Ab-1/ GM-Tg-rg-T08919-Ab-2Anti-Rat CDH1 monoclonal antibodyRat
GM-Tg-mg-T08919-Ab-1/ GM-Tg-mg-T08919-Ab-2Anti-Mouse CDH1 monoclonal antibodyMouse
GM-Tg-cynog-T08919-Ab-1/ GM-Tg-cynog-T08919-Ab-2Anti-Cynomolgus/ Rhesus macaque CDH1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T08919-Ab-1/ GM-Tg-felg-T08919-Ab-2Anti-Feline CDH1 monoclonal antibodyFeline
GM-Tg-cang-T08919-Ab-1/ GM-Tg-cang-T08919-Ab-2Anti-Canine CDH1 monoclonal antibodyCanine
GM-Tg-bovg-T08919-Ab-1/ GM-Tg-bovg-T08919-Ab-2Anti-Bovine CDH1 monoclonal antibodyBovine
GM-Tg-equg-T08919-Ab-1/ GM-Tg-equg-T08919-Ab-2Anti-Equine CDH1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T08919-Ab-1/ GM-Tg-hg-T08919-Ab-2; GM-Tg-rg-T08919-Ab-1/ GM-Tg-rg-T08919-Ab-2;
GM-Tg-mg-T08919-Ab-1/ GM-Tg-mg-T08919-Ab-2; GM-Tg-cynog-T08919-Ab-1/ GM-Tg-cynog-T08919-Ab-2;
GM-Tg-felg-T08919-Ab-1/ GM-Tg-felg-T08919-Ab-2; GM-Tg-cang-T08919-Ab-1/ GM-Tg-cang-T08919-Ab-2;
GM-Tg-bovg-T08919-Ab-1/ GM-Tg-bovg-T08919-Ab-2; GM-Tg-equg-T08919-Ab-1/ GM-Tg-equg-T08919-Ab-2
Products NameAnti-CDH1 monoclonal antibody
Formatmab
Target NameCDH1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CDH1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CADH1/ CDH1/ Arc-1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000571human CDH1 Lentivirus plasmid
    ORF Viral VectorpGMAD000168human CDH1 Adenovirus plasmid
    ORF Viral VectorvGMAD000168human CDH1 Adenovirus particle
    ORF Viral VectorvGMLV000571human CDH1 Lentivirus particle
    ORF Viral VectorpGMLV000156mouse Cdh1 Lentivirus plasmid
    ORF Viral VectorvGMLV000156mouse Cdh1 Lentivirus particle


    Target information

    Target IDGM-T08919
    Target NameCDH1
    Gene ID999,12550,83502,704387,442858,101095391,100066844
    Gene Symbol and SynonymsArc-1,BCDS1,Cadherin-1,CD324,CDH1,CDHE,E-cad,ECAD,L-CAM,LCAM,Um,UVO,Uvomorulin
    Uniprot AccessionP12830,Q9R0T4,F1PAA9
    Uniprot Entry NameCADH1_HUMAN,CADH1_RAT,CADH1_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseBreast Cancer, Type 2 diabetes mellitus, Diabetic Nephropathy, Congenital occlusion of ureteropelvic junction, Gastric cancer
    Gene EnsemblENSG00000039068
    Target ClassificationN/A

    The target: CDH1, gene name: CDH1, also named as Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM, UVO. This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.