TP53: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of TP53. The page also collects GeneMedi's different modalities and formats products for TP53 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TP53 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Introcelluar Protein.

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Target IDGM-T15739
Target NameTP53
Gene ID7157,22059,24842,716170,403869,493847,281542,100062044
Gene Symbol and Synonymsbbl,BCC7,bfy,bhy,BMFS5,LFS1,p44,P53,TP53,TRP53
Uniprot AccessionP04637,P10361,P56424,Q29537,P41685,P67939,P79892
Protein Sub-locationIntrocelluar Protein
DiseaseLung Cancer, lung cancers, Lung cancer, Lung, Colon cancer, Bone metastasis, Liver neoplasms, Lung neoplasms
Gene EnsemblENSG00000141510
Target ClassificationN/A

Pre-made anti-TP53 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-TP53 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TP53 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-TP53 monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabDetail

Recombinant multi-species P53/ TP53/ BCC7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TP53 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
TP53 proteinHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellDetail

Pre-made TP53 viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
vGMAAV000014human TP53 AAV particleNM_001126112.2HumanAAV particleDetail
pGMAP000334Human TP53 Adenovirus plasmidBC003596HumanAdenovirus plasmidDetail
pGMAD000013human TP53 Adenovirus plasmidNM_000546.5HumanAdenovirus plasmidDetail
vGMAD000013human TP53 Adenovirus particleNM_000546.5HumanAdenovirus particleDetail
pGMAAV000014human TP53 AAV plasmidNM_001126112.2HumanAAV plasmidDetail
vGMAP000334Human TP53 Adenovirus particleBC003596HumanAdenovirus particleDetail
pGMAD000347rat Tp53 Adenovirus plasmidNM_030989RatAdenovirus plasmidDetail
vGMAD000347rat Tp53 Adenovirus particleNM_030989RatAdenovirus particleDetail
pGMAD000539house mouse Trp53 Adenovirus plasmidNM_011640.3House MouseAdenovirus plasmidDetail
vGMAD000539house mouse Trp53 Adenovirus particleNM_011640.3House MouseAdenovirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.

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