TP53: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of TP53. The page also collects GeneMedi's different modalities and formats products for TP53 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TP53 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
|Gene Symbol and Synonyms||bbl,BCC7,bfy,bhy,BMFS5,LFS1,p44,P53,TP53,TRP53|
|Uniprot Entry Name||P53_HUMAN,P53_MACMU,P53_RAT,P53_FELCA,P53_CANLF,P53_BOVIN,P53_HORSE|
|Protein Sub-location||Introcelluar Protein|
|Disease||Lung Cancer, lung cancers, Lung cancer, Lung, Colon cancer, Bone metastasis, Liver neoplasms, Lung neoplasms|
Pre-made anti-TP53 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-TP53 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TP53 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
|Antibody Name||Species||Format||Classified by tag||Detail|
|Anti-TP53 monoclonal antibody||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||mab||Detail|
Recombinant multi-species P53/ TP53/ BCC7 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TP53 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
|Products Name||Species||Expression Platform||Detail|
|TP53 protein||Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine||Mammalian cell||Detail|
Pre-made TP53 viral vector in GM Promise-ORFTM
|Cat No.||Products name||NM ID||Species||Type||Detail|
|vGMAAV000014||human TP53 AAV particle||NM_001126112.2||Human||AAV particle||Detail|
|pGMAP000334||Human TP53 Adenovirus plasmid||BC003596||Human||Adenovirus plasmid||Detail|
|pGMAD000013||human TP53 Adenovirus plasmid||NM_000546.5||Human||Adenovirus plasmid||Detail|
|vGMAD000013||human TP53 Adenovirus particle||NM_000546.5||Human||Adenovirus particle||Detail|
|pGMAAV000014||human TP53 AAV plasmid||NM_001126112.2||Human||AAV plasmid||Detail|
|vGMAP000334||Human TP53 Adenovirus particle||BC003596||Human||Adenovirus particle||Detail|
|pGMAD000347||rat Tp53 Adenovirus plasmid||NM_030989||Rat||Adenovirus plasmid||Detail|
|vGMAD000347||rat Tp53 Adenovirus particle||NM_030989||Rat||Adenovirus particle||Detail|
|pGMAD000539||house mouse Trp53 Adenovirus plasmid||NM_011640.3||House Mouse||Adenovirus plasmid||Detail|
|vGMAD000539||house mouse Trp53 Adenovirus particle||NM_011640.3||House Mouse||Adenovirus particle||Detail|
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.