CLU: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of CLU. The page also collects GeneMedi's different modalities and formats products for CLU in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the CLU target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Secreted Protein/Potential Cytokines.

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]

Target IDGM-T96669
Target NameCLU
Gene ID1191,12759,24854,677866,442971,101092846,280750,100034172
Gene Symbol and SynonymsAAG4,APO-J,APOJ,CLI,CLU,CLU1,CLU2,D14Ucla3,DAG,GP80,gpIII,KUB1,NA1/NA2,RATTRPM2B,SGP-2,SGP2,SP-40,SP40,Sugp-2,TRPM-2,TRPM2,TRPM2B,Trpmb
Uniprot AccessionP10909,P05371,P25473,P17697,Q29482
Uniprot Entry NameCLUS_HUMAN,CLUS_RAT,CLUS_CANLF,CLUS_BOVIN,CLUS_HORSE
Protein Sub-locationSecreted Protein/Potential Cytokines
CategoryTherapeutics Target, INN Index
Diseaseleukemia patients, Acute kidney failure, Dent disease, Type 2 diabetes mellitus
Gene EnsemblENSG00000120885
Target ClassificationN/A


Pre-made CLU-specific INN-index biosimilar (antibody&conjugates)

Anti-CLU therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.Products Name (INN Index)INN Name Previous Name Target FormatDetail
GMP-Bios-ab-696Pre-Made Sotevtamab biosimilar, Whole mAb, Anti-CLU/Clusterinm Antibody: Anti-AAG4/APO-J/APOJ/CLI/KUB1/NA1/NA2/SGP-2/SGP2/SP-40/TRPM-2/TRPM2 therapeutic antibodySotevtamabCLU/ClusterinWhole mAbDetail

Click to check more INN-indexed antibody & protein biosimilar



Pre-made anti-CLU inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-CLU benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-CLU mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-CLU monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail



Recombinant multi-species CLUS/ CLU/ AAG4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CLU protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
CLU proteinHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellDetail



Pre-made CLU viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
vGMAD000502human CLU Adenovirus particleNM_001831.3HumanAdenovirus particleDetail
vGMLV000313human CLU Lentivirus particleNM_001831.3HumanLentivirus particleDetail
pGMLV000313human CLU Lentivirus plasmidNM_001831.3HumanLentivirus plasmidDetail
vGMAD000637human CLU Adenovirus particleNM_001831.3HumanAdenovirus particleDetail
pGMAD000502human CLU Adenovirus plasmidNM_001831.3HumanAdenovirus plasmidDetail
pGMAD000637human CLU Adenovirus plasmidNM_001831.3HumanAdenovirus plasmidDetail
pGMAAV000344Norway rat Clu AAV plasmidNM_053021.2Norway RatAAV plasmidDetail
pGMAAV000345house mouse Clu AAV plasmidNM_013492.3House MouseAAV plasmidDetail
pGMLPm004458mouse Clu Lentivirus plasmidNM_013492MouseLentivirus plasmidDetail
vGMAAV000344Norway rat Clu AAV particleNM_053021.2Norway RatAAV particleDetail
vGMAAV000345house mouse Clu AAV particleNM_013492.3House MouseAAV particleDetail
vGMLPm004458mouse Clu Lentivirus particleNM_013492MouseLentivirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.






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