DCN: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of DCN. The page also collects GeneMedi's different modalities and formats products for DCN in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the DCN target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
Target ID | GM-T67883 |
Target Name | DCN |
Gene ID | 1634,13179,29139,709933,403904,101101236,280760,100034120 |
Gene Symbol and Synonyms | CSCD,DC,DCN,DSPG2,PG40,PGII,PGS2,SLRR1B |
Uniprot Accession | P07585,Q01129,Q29393,P21793,O46542 |
Uniprot Entry Name | PGS2_HUMAN,PGS2_RAT,PGS2_CANLF,PGS2_BOVIN,PGS2_HORSE |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000011465 |
Target Classification | N/A |
Pre-made anti-DCN inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-DCN benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-DCN mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-DCN monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Recombinant multi-species PGS2/ DCN/ CSCD protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DCN protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
DCN protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made DCN viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMAP000037 | Human DCN Adenovirus particle | BC005322 | Human | Adenovirus particle | Detail |
pGMLP001350 | human NM_001920humanNM_001920 Lentivirus plasmid | NM_001920 | Human | Lentivirus plasmid | Detail |
pGMAP000037 | Human DCN Adenovirus plasmid | BC005322 | Human | Adenovirus plasmid | Detail |
pGMAD000132 | human DCN Adenovirus plasmid | NM_001920 | Human | Adenovirus plasmid | Detail |
vGMAD000132 | human DCN Adenovirus particle | NM_001920 | Human | Adenovirus particle | Detail |
vGMLP001350 | human NM_001920humanNM_001920 Lentivirus particle | NM_001920 | Human | Lentivirus particle | Detail |
pGMLPm001658 | mouse Dcn Lentivirus plasmid | NM_007833 | Mouse | Lentivirus plasmid | Detail |
vGMLPm001658 | mouse Dcn Lentivirus particle | NM_007833 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.