UCP2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of UCP2. The page also collects GeneMedi's different modalities and formats products for UCP2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the UCP2 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
Target ID | GM-T84560 |
Target Name | UCP2 |
Gene ID | 7351,22228,54315,574198,403576,692194,281562,100052144 |
Gene Symbol and Synonyms | BMIQ4,SLC25A8,UCP 2,UCP2,UCPH |
Uniprot Accession | P55851,P56500,Q9N2J1,Q3SZI5 |
Uniprot Entry Name | UCP2_HUMAN,UCP2_RAT,UCP2_CANLF,UCP2_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000175567 |
Target Classification | N/A |
Pre-made anti-UCP2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-UCP2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-UCP2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-UCP2 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species UCP2/ BMIQ4/ SLC25A8 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine UCP2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
UCP2 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made UCP2 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMLP000084 | human UCP2 Lentivirus particle | NM_003355 | Human | Lentivirus particle | Detail |
pGMLP000084 | human UCP2 Lentivirus plasmid | NM_003355 | Human | Lentivirus plasmid | Detail |
pGMAD000297 | rat Ucp2 Adenovirus plasmid | NM_019354.2 | Rat | Adenovirus plasmid | Detail |
pGMAAV000146 | rat Ucp2 AAV plasmid | NM_019354.3 | Rat | AAV plasmid | Detail |
pGMAAV000337 | Norway rat Ucp2 AAV plasmid | NM_019354.3 | Norway Rat | AAV plasmid | Detail |
pGMLPm000329 | mouse Ucp2 Lentivirus plasmid | NM_011671 | Mouse | Lentivirus plasmid | Detail |
vGMAD000297 | rat Ucp2 Adenovirus particle | NM_019354.2 | Rat | Adenovirus particle | Detail |
vGMAAV000146 | rat Ucp2 AAV particle | NM_019354.3 | Rat | AAV particle | Detail |
vGMAAV000337 | Norway rat Ucp2 AAV particle | NM_019354.3 | Norway Rat | AAV particle | Detail |
vGMLPm000329 | mouse Ucp2 Lentivirus particle | NM_011671 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.