ATP2A2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of ATP2A2. The page also collects GeneMedi's different modalities and formats products for ATP2A2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the ATP2A2 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
Target ID | GM-IP0055 |
Target Name | ATP2A2 |
Gene ID | 488,11938,29693,710702,403878,493691,540568,791242 |
Gene Symbol and Synonyms | 9530097L16Rik,ATP2A2,ATP2B,D5Wsu150e,DAR,DD,mKIAA4195,SERCA2,Serca2a,SERCA2B,SercaII |
Uniprot Accession | P16615,P11507,O46674,Q00779 |
Uniprot Entry Name | AT2A2_HUMAN,AT2A2_RAT,AT2A2_FELCA,AT2A2_CANLF |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000174437 |
Target Classification | N/A |
Pre-made anti-ATP2A2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-ATP2A2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-ATP2A2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-ATP2A2 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species AT2A2/ ATP2A2/ ATP2B protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ATP2A2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
ATP2A2 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made ATP2A2 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMAD000481 | human ATP2A2 Adenovirus plasmid | NM_170665 | Human | Adenovirus plasmid | Detail |
vGMAD000382 | human ATP2A2 Adenovirus particle | NM_170665 | Human | Adenovirus particle | Detail |
pGMAP000495 | Human ATP2A2 Adenovirus plasmid | BC035588 | Human | Adenovirus plasmid | Detail |
pGMAD000382 | human ATP2A2 Adenovirus plasmid | NM_170665 | Human | Adenovirus plasmid | Detail |
pGMAAV000157 | human ATP2A2 AAV plasmid | NM_170665 | Human | AAV plasmid | Detail |
vGMAP000495 | Human ATP2A2 Adenovirus particle | BC035588 | Human | Adenovirus particle | Detail |
vGMAAV000157 | human ATP2A2 AAV particle | NM_170665 | Human | AAV particle | Detail |
vGMAD000481 | human ATP2A2 Adenovirus particle | NM_170665 | Human | Adenovirus particle | Detail |
pGMAD000225 | mouse Atp2a2 Adenovirus plasmid | NM_009722.3 | Mouse | Adenovirus plasmid | Detail |
pGMAD000455 | house mouse Atp2a2 Adenovirus plasmid | NM_009722.3 | House Mouse | Adenovirus plasmid | Detail |
vGMAD000225 | mouse Atp2a2 Adenovirus particle | NM_009722.3 | Mouse | Adenovirus particle | Detail |
vGMAD000455 | house mouse Atp2a2 Adenovirus particle | NM_009722.3 | House Mouse | Adenovirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.