Anti-ATP2A2 monoclonal antibody
Pre-made anti-ATP2A2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-IP0055-Ab-1/ GM-Tg-hg-IP0055-Ab-2 | Anti-Human ATP2A2 monoclonal antibody | Human |
GM-Tg-rg-IP0055-Ab-1/ GM-Tg-rg-IP0055-Ab-2 | Anti-Rat ATP2A2 monoclonal antibody | Rat |
GM-Tg-mg-IP0055-Ab-1/ GM-Tg-mg-IP0055-Ab-2 | Anti-Mouse ATP2A2 monoclonal antibody | Mouse |
GM-Tg-cynog-IP0055-Ab-1/ GM-Tg-cynog-IP0055-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ATP2A2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-IP0055-Ab-1/ GM-Tg-felg-IP0055-Ab-2 | Anti-Feline ATP2A2 monoclonal antibody | Feline |
GM-Tg-cang-IP0055-Ab-1/ GM-Tg-cang-IP0055-Ab-2 | Anti-Canine ATP2A2 monoclonal antibody | Canine |
GM-Tg-bovg-IP0055-Ab-1/ GM-Tg-bovg-IP0055-Ab-2 | Anti-Bovine ATP2A2 monoclonal antibody | Bovine |
GM-Tg-equg-IP0055-Ab-1/ GM-Tg-equg-IP0055-Ab-2 | Anti-Equine ATP2A2 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-IP0055-Ab-1/ GM-Tg-hg-IP0055-Ab-2; GM-Tg-rg-IP0055-Ab-1/ GM-Tg-rg-IP0055-Ab-2; GM-Tg-mg-IP0055-Ab-1/ GM-Tg-mg-IP0055-Ab-2; GM-Tg-cynog-IP0055-Ab-1/ GM-Tg-cynog-IP0055-Ab-2; GM-Tg-felg-IP0055-Ab-1/ GM-Tg-felg-IP0055-Ab-2; GM-Tg-cang-IP0055-Ab-1/ GM-Tg-cang-IP0055-Ab-2; GM-Tg-bovg-IP0055-Ab-1/ GM-Tg-bovg-IP0055-Ab-2; GM-Tg-equg-IP0055-Ab-1/ GM-Tg-equg-IP0055-Ab-2 |
Products Name | Anti-ATP2A2 monoclonal antibody |
Format | mab |
Target Name | ATP2A2 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-ATP2A2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-IP0055-Ag-1 | Recombinant multi-species AT2A2/ ATP2A2/ ATP2B protein |
ORF Viral Vector | pGMAD000481 | human ATP2A2 Adenovirus plasmid |
ORF Viral Vector | vGMAD000382 | human ATP2A2 Adenovirus particle |
ORF Viral Vector | pGMAP000495 | Human ATP2A2 Adenovirus plasmid |
ORF Viral Vector | pGMAD000382 | human ATP2A2 Adenovirus plasmid |
ORF Viral Vector | pGMAAV000157 | human ATP2A2 AAV plasmid |
ORF Viral Vector | vGMAP000495 | Human ATP2A2 Adenovirus particle |
ORF Viral Vector | vGMAAV000157 | human ATP2A2 AAV particle |
ORF Viral Vector | vGMAD000481 | human ATP2A2 Adenovirus particle |
ORF Viral Vector | pGMAD000225 | mouse Atp2a2 Adenovirus plasmid |
ORF Viral Vector | pGMAD000455 | house mouse Atp2a2 Adenovirus plasmid |
ORF Viral Vector | vGMAD000225 | mouse Atp2a2 Adenovirus particle |
ORF Viral Vector | vGMAD000455 | house mouse Atp2a2 Adenovirus particle |
Target information
Target ID | GM-IP0055 |
Target Name | ATP2A2 |
Gene ID | 488,11938,29693,710702,403878,493691,540568,791242 |
Gene Symbol and Synonyms | 9530097L16Rik,ATP2A2,ATP2B,D5Wsu150e,DAR,DD,mKIAA4195,SERCA2,Serca2a,SERCA2B,SercaII |
Uniprot Accession | P16615,P11507,O46674,Q00779 |
Uniprot Entry Name | AT2A2_HUMAN,AT2A2_RAT,AT2A2_FELCA,AT2A2_CANLF |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | N/A |
Gene Ensembl | ENSG00000174437 |
Target Classification | N/A |
The target: ATP2A2, gene name: ATP2A2, also named as ATP2B, DAR, DD, SERCA2. This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.