Human ATP2A2/ATP2B/ DAR ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_170665)
Pre-made Human ATP2A2/ATP2B/ DAR Adeno-associated virus expression plasmid (ITR-vector) for ATP2A2 AAV packaging, ATP2A2 AAV production.The purified Human ATP2A2/ATP2B/ DAR AAV particle serves as an invaluable asset for in-depth in vivo ATP2A2 studies, mechanism of action (MOA) research, and the evolution of ATP2A2-associated gene therapy strategies.
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Product information
Catalog No. | Product Name | Plasmid Grade | Plasmid quantity |
---|---|---|---|
pGMAAV000157 | Human ATP2A2 Adeno-associate virus(AAV) plasmid | Research Grade | 10mg, 50mg, 100mg, 500mg, >1g |
GMP-like Grade | 10mg, 50mg, 100mg, 500mg, >1g | ||
High Quality (HQ) Grade | |||
Seed | 5ug |
Product Description
Catalog ID | pGMAAV000157 |
Gene Name | ATP2A2 |
Accession Number | NM_170665 |
Gene ID | 488 |
Species | Human |
Product Type | Adeno-associate virus(AAV) plasmid (overexpression) |
Insert Length | 3129 bp |
Gene Alias | ATP2B, DAR, DD, SERCA2 |
Fluorescent Reporter | EGFP |
Mammalian Cell Selection | |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
---|---|---|
Target Antibody | GM-Tg-g-IP0055-Ab | Anti-ATP2A2 monoclonal antibody |
Target Antigen | GM-Tg-g-IP0055-Ag | ATP2A2 protein |
ORF Viral Vector | pGMAD000382 | Human ATP2A2 Adenovirus plasmid |
ORF Viral Vector | pGMAD000481 | Human ATP2A2 Adenovirus plasmid |
ORF Viral Vector | pGMAAV000157 | Human ATP2A2 Adeno-associate virus(AAV) plasmid |
ORF Viral Vector | pGMAP000495 | Human ATP2A2 Adenovirus plasmid |
ORF Viral Vector | vGMAD000382 | Human ATP2A2 Adenovirus particle |
ORF Viral Vector | vGMAD000481 | Human ATP2A2 Adenovirus particle |
ORF Viral Vector | vGMAAV000157 | Human ATP2A2 Adeno-associate virus(AAV) particle |
ORF Viral Vector | vGMAP000495 | Human ATP2A2 Adenovirus particle |
Target information
Target ID | GM-IP0055 |
Target Name | ATP2A2 |
Gene ID | 488, 11938, 710702, 29693, 493691, 403878, 540568, 791242 |
Gene Symbol and Synonyms | 9530097L16Rik,ATP2A2,ATP2B,D5Wsu150e,DAR,DD,mKIAA4195,SERCA2,Serca2a,SERCA2B,SercaII |
Uniprot Accession | P16615 |
Uniprot Entry Name | AT2A2_HUMAN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Not Available |
Gene Ensembl | ENSG00000174437 |
Target Classification | Not Available |
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of the skeletal muscle. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Other types of mutations in this gene have been associated with various forms of muscular dystrophies. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
About GMVC
GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.