BGLAP: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of BGLAP. The page also collects GeneMedi's different modalities and formats products for BGLAP in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the BGLAP target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Target ID | GM-SE0683 |
Target Name | BGLAP |
Gene ID | 632,12096,25295,718296,403762,101085947,281646 |
Gene Symbol and Synonyms | BGLAP,Bglap1,Bglap2,BGP,Bgpr,Bgpra,GLA,mOC-A,OC,OCN,OG1 |
Uniprot Accession | P02818, P84351,P04640,A2D670,P81455,P02820 |
Uniprot Entry Name | OSTCN_HOMNE,OSTCN_MACMU,OSTCN_RAT,OSTCN_CANLF,OSTCN_BOVIN |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | |
Disease | Breast Cancer, bone formation, Disturbances in bone turnover, glucocorticoid-induced osteopenia, growth |
Gene Ensembl | ENSG00000242252 |
Target Classification | N/A |
Pre-made anti-BGLAP inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-BGLAP benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-BGLAP mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-BGLAP monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody | Detail |
Recombinant multi-species OSTCN/ OSTCN_HOMNE/ BGLAP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BGLAP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
BGLAP protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made BGLAP viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMLP000550 | human BGLAP Lentivirus plasmid | NM_199173 | Human | Lentivirus plasmid | Detail |
vGMAP000480 | Human BGLAP Adenovirus particle | BC113432 | Human | Adenovirus particle | Detail |
pGMAP000480 | Human BGLAP Adenovirus plasmid | BC113432 | Human | Adenovirus plasmid | Detail |
vGMLP000550 | human BGLAP Lentivirus particle | NM_199173 | Human | Lentivirus particle | Detail |
pGMLPm003726 | mouse Bglap Lentivirus plasmid | NM_007541.3 | Mouse | Lentivirus plasmid | Detail |
vGMLPm003726 | mouse Bglap Lentivirus particle | NM_007541.3 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.