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Anti-OSTCN/ OSTCN_HOMNE/ BGLAP functional antibody
Anti-OSTCN/ OSTCN_HOMNE/ BGLAP functional antibody for cell culture, ELISA & in-vivo assay
Go to BGLAP/BGLAP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0683-Ab-1/ GM-Tg-hg-SE0683-Ab-2 | Anti-Human BGLAP monoclonal antibody | Human |
| GM-Tg-rg-SE0683-Ab-1/ GM-Tg-rg-SE0683-Ab-2 | Anti-Rat BGLAP monoclonal antibody | Rat |
| GM-Tg-mg-SE0683-Ab-1/ GM-Tg-mg-SE0683-Ab-2 | Anti-Mouse BGLAP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0683-Ab-1/ GM-Tg-cynog-SE0683-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BGLAP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0683-Ab-1/ GM-Tg-felg-SE0683-Ab-2 | Anti-Feline BGLAP monoclonal antibody | Feline |
| GM-Tg-cang-SE0683-Ab-1/ GM-Tg-cang-SE0683-Ab-2 | Anti-Canine BGLAP monoclonal antibody | Canine |
| GM-Tg-bovg-SE0683-Ab-1/ GM-Tg-bovg-SE0683-Ab-2 | Anti-Bovine BGLAP monoclonal antibody | Bovine |
| GM-Tg-equg-SE0683-Ab-1/ GM-Tg-equg-SE0683-Ab-2 | Anti-Equine BGLAP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0683-Ab-1/ GM-Tg-hg-SE0683-Ab-2; GM-Tg-rg-SE0683-Ab-1/ GM-Tg-rg-SE0683-Ab-2; GM-Tg-mg-SE0683-Ab-1/ GM-Tg-mg-SE0683-Ab-2; GM-Tg-cynog-SE0683-Ab-1/ GM-Tg-cynog-SE0683-Ab-2; GM-Tg-felg-SE0683-Ab-1/ GM-Tg-felg-SE0683-Ab-2; GM-Tg-cang-SE0683-Ab-1/ GM-Tg-cang-SE0683-Ab-2; GM-Tg-bovg-SE0683-Ab-1/ GM-Tg-bovg-SE0683-Ab-2; GM-Tg-equg-SE0683-Ab-1/ GM-Tg-equg-SE0683-Ab-2 |
| Products Name | Anti-BGLAP monoclonal antibody |
| Format | mab |
| Target Name | BGLAP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-BGLAP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0683-Ag-1 | Recombinant multi-species OSTCN/ OSTCN_HOMNE/ BGLAP protein |
| ORF Viral Vector | pGMLP000550 | human BGLAP Lentivirus plasmid |
| ORF Viral Vector | vGMAP000480 | Human BGLAP Adenovirus particle |
| ORF Viral Vector | pGMAP000480 | Human BGLAP Adenovirus plasmid |
| ORF Viral Vector | vGMLP000550 | human BGLAP Lentivirus particle |
| ORF Viral Vector | pGMLPm003726 | mouse Bglap Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003726 | mouse Bglap Lentivirus particle |
Target information
| Target ID | GM-SE0683 |
| Target Name | BGLAP |
| Gene ID | 632,12096,25295,718296,403762,101085947,281646 |
| Gene Symbol and Synonyms | BGLAP,Bglap1,Bglap2,BGP,Bgpr,Bgpra,GLA,mOC-A,OC,OCN,OG1 |
| Uniprot Accession | P02818, P84351,P04640,A2D670,P81455,P02820 |
| Uniprot Entry Name | OSTCN_HOMNE,OSTCN_MACMU,OSTCN_RAT,OSTCN_CANLF,OSTCN_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Breast Cancer, bone formation, Disturbances in bone turnover, glucocorticoid-induced osteopenia, growth |
| Gene Ensembl | ENSG00000242252 |
| Target Classification | N/A |
The target: BGLAP, gene name: BGLAP, also named as BGP, OC, OCN. This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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