Canine Pregnancy Specific Protein B antibody and antigen (recombinant protein)

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Diagnostic anti-Canine Pregnancy Specific Protein B antibodies pairs and antigen for animal health (animal Dog/Canine) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Validation Data

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Target/Biomarker Information

Pregnancy-Specific Protein B (PSPB) is primarily associated with bovine pregnancy as a biomarker for early detection. In dogs (canines), PSPB is not a recognized marker for pregnancy detection. Instead, canine pregnancy diagnosis relies on different methods and markers, including:

Relaxin: Relaxin is a hormone produced by the placental tissues in pregnant dogs and serves as a key biochemical marker for confirming pregnancy. Commercial tests are available to detect relaxin in the blood serum of pregnant dogs, typically from about 22 to 30 days post-breeding. Relaxin's presence at elevated levels is a reliable indicator of pregnancy because its production is closely associated with the development of the placenta.

Ultrasound: Ultrasound examination is a common and reliable method for diagnosing pregnancy in dogs, usually starting around 25 to 30 days post-breeding. It allows for the visualization of the gestational sacs and, later in the pregnancy, fetal structures and heartbeats.

Radiography (X-rays): X-rays are another diagnostic tool, generally used later in pregnancy (around 45 to 55 days post-breeding) to determine the number of fetuses and assess fetal development and skeletal structure. This method is not suitable for early pregnancy detection but is valuable for planning for whelping.

Physical Examination and Hormonal Changes: Veterinarians may also use physical examination findings and changes in hormonal levels (other than relaxin) to infer pregnancy. However, these methods are less specific and can be influenced by other factors.

Progesterone Levels: While not a direct marker of pregnancy, monitoring progesterone levels can help confirm ovulation and optimal breeding times, indirectly aiding in the prediction of a successful pregnancy.

In summary, while PSPB is a specific marker used in cattle, canine pregnancy diagnosis does not rely on PSPB but rather on a combination of hormonal assays (like relaxin), imaging techniques (ultrasound and radiography), and physical examination findings. These methods collectively offer a comprehensive approach to confirming pregnancy in dogs.

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