Equine Pregnancy-associated glycoprotein 1 antibody and antigen (recombinant protein)

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Diagnostic anti-Equine Pregnancy-associated glycoprotein 1 antibodies pairs and antigen for animal health (animal Equine/Horse) testing in ELISA, colloidal gold-based Lateral flow immunoassay (LFIA), CLIA, TINIA and POCT

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Reference

Validation Data

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Target/Biomarker Information

As of the last update in April 2023, the specific mention and study of Pregnancy-associated glycoprotein 1 (PAG1) in equine (horse) pregnancy diagnostics are not prominently featured in mainstream veterinary practices or research literature. The concept and application of pregnancy-associated glycoproteins (PAGs) have been extensively documented in ruminants, particularly in cattle, where they serve as important markers for the detection and monitoring of pregnancy. PAGs are a diverse group of proteins produced by the placental trophoblast cells, and they play roles in modulating the maternal immune system to support pregnancy maintenance and development.

In equine reproductive management, several other methods and biomarkers are traditionally relied upon for the diagnosis and monitoring of pregnancy:

Ultrasound Examination: This is the primary method for early pregnancy diagnosis in horses, allowing for the detection of a gestational sac as early as 14 days post-ovulation and visualization of the developing embryo and fetal heartbeat in later stages.

eCG (Equine Chorionic Gonadotropin) Testing: Also known as PMSG (Pregnant Mare Serum Gonadotropin), eCG is a hormone produced by the endometrial cups of the pregnant mare between approximately days 40 and 120 of gestation. Its presence in the blood can be used to confirm pregnancy.

Progesterone Levels: Monitoring progesterone levels helps ensure that the mare maintains a pregnancy-supportive hormonal environment, although this is not a direct test for pregnancy itself.

Physical Signs and Behavioral Changes: Some physical and behavioral changes may suggest pregnancy, but these are not reliable without confirmation from more specific diagnostic methods.

Rectal Palpation: Experienced veterinarians can perform rectal palpation to feel the developing fetus or changes in the mare's reproductive tract indicative of pregnancy, particularly in the later stages.

The role of PAGs, including PAG1, in equine pregnancy detection is not as clearly established or utilized as in cattle, where specific PAG assays have been developed for pregnancy diagnosis. The exploration of PAGs in horses may offer interesting insights into equine placental biology and reproductive physiology, but as of now, the focus on equine PAGs in clinical practice is limited.

Research in equine reproductive biology continues to evolve, and future studies may uncover more about the presence and significance of PAGs in horse pregnancy. For the most current and detailed information on equine pregnancy diagnosis and the potential role of emerging biomarkers like PAG1, consultation with veterinary reproductive specialists and review of the latest scientific literature are recommended.

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