EZH2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of EZH2. The page also collects GeneMedi's different modalities and formats products for EZH2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the EZH2 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Introcelluar Protein.

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Target IDGM-T25265
Target NameEZH2
Gene ID2146,14056,312299,709075,475511,101087309,509106,100051290
Gene Symbol and SynonymsENX-1,ENX1,Enx1h,EZH2,EZH2b,KMT6,KMT6A,mKIAA4065,WVS,WVS2
Uniprot AccessionQ15910
Uniprot Entry NameEZH2_HUMAN
Protein Sub-locationIntrocelluar Protein
CategoryTherapeutics Target
Gene EnsemblENSG00000106462
Target ClassificationTumor-associated antigen (TAA)

Pre-made anti-EZH2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-EZH2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-EZH2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-EZH2 monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabTherapeutics Target antibodyDetail

Recombinant multi-species EZH2/ ENX-1/ ENX1b protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine EZH2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
EZH2 proteinHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellDetail

Pre-made EZH2 viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
vGMLV000239human EZH2 Lentivirus particleNM_004456.4HumanLentivirus particleDetail
pGMLV000587human EZH2 Lentivirus plasmidNM_004456.4HumanLentivirus plasmidDetail
vGMLV000587human EZH2 Lentivirus particleNM_004456.4HumanLentivirus particleDetail
pGMLV000239human EZH2 Lentivirus plasmidNM_004456.4HumanLentivirus plasmidDetail
pGMAD000205mouse Ezh2 Adenovirus plasmidNM_007971.2MouseAdenovirus plasmidDetail
pGMAD000643house mouse Ezh2 Adenovirus plasmidNM_001146689House MouseAdenovirus plasmidDetail
pGMAD000644house mouse Ezh2 Adenovirus plasmidNM_007971House MouseAdenovirus plasmidDetail
pGMAAV000342house mouse Ezh2 AAV plasmidNM_007971.2House MouseAAV plasmidDetail
pGMAAV000343house mouse Ezh2 AAV plasmidNM_001146689.1House MouseAAV plasmidDetail
vGMAD000205mouse Ezh2 Adenovirus particleNM_007971.2MouseAdenovirus particleDetail
vGMAD000643house mouse Ezh2 Adenovirus particleNM_001146689House MouseAdenovirus particleDetail
vGMAD000644house mouse Ezh2 Adenovirus particleNM_007971House MouseAdenovirus particleDetail
vGMAAV000342house mouse Ezh2 AAV particleNM_007971.2House MouseAAV particleDetail
vGMAAV000343house mouse Ezh2 AAV particleNM_001146689.1House MouseAAV particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.

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