MSTN,GDF-8: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of GDF-8,MSTN. The page also collects GeneMedi's different modalities and formats products for GDF-8 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the GDF-8 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Secreted Protein/Potential Cytokines.

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Mutations in this gene are associated with increased skeletal muscle mass in humans and other mammals. [provided by RefSeq, Jul 2016]

Pre-made GDF-8-specific INN-index biosimilar (antibody&conjugates)-ramatercept, stamulumab, Trevogrumab, Domagrozumab, Landogrozumab, efmitermant alfa, taldefgrobep alfa

Anti-GDF-8 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.	Products Name (INN Index)	INN Name	Previous Name	Target	Format	Order
GMP-Bios-INN-967	Pre-Made Ramatercept Biosimilar, Fusion Protein targeting MSTN/GDF-8 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting GDF8/MSLHP	ramatercept		MSTN/GDF-8	Fusion Protein
GMP-Bios-INN-999	Pre-Made Stamulumab Biosimilar, Whole Mab, Anti-MSTN/GDF-8 Antibody: Anti-GDF8/MSLHP therapeutic antibody	stamulumab		MSTN/GDF-8	Whole  mAb
GMP-Bios-ab-596	Pre-Made Trevogrumab biosimilar, Whole mAb, Anti-MSTN/GDF-8 Antibody: Anti-GDF8/MSLHP therapeutic antibody	Trevogrumab		MSTN/GDF-8	Whole mAb
GMP-Bios-ab-151	Pre-Made Domagrozumab biosimilar, Whole mAb, Anti-MSTN/GDF-8 Antibody: Anti-GDF8/MSLHP therapeutic antibody	Domagrozumab		MSTN/GDF-8	Whole mAb
GMP-Bios-ab-295	Pre-Made Landogrozumab biosimilar, Whole mAb, Anti-MSTN/GDF-8 Antibody: Anti-GDF8/MSLHP therapeutic antibody	Landogrozumab		MSTN/GDF-8	Whole mAb
GMP-Bios-INN-822	Pre-Made Efmitermant Alfa Biosimilar, Fusion Protein targeting MSTN/GDF-8 fused with human IGHG2 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting GDF8/MSLHP	efmitermant alfa		MSTN/GDF-8	Fusion Protein
GMP-Bios-INN-1004	Pre-Made Taldefgrobep Alfa Biosimilar, Fusion Protein targeting MSTN/GDF-8 fused with human IGHG1 Fc (Fragment constant) via a peptidyl linker: Recombinant therapeutic protein targeting GDF8/MSLHP	taldefgrobep alfa		MSTN/GDF-8	Fusion Protein

Pre-made anti-GDF-8 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-GDF-8 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-GDF-8 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Cat No.	Antibody Name	Format	Classified by tag	Order
GM-Tg-hg-T87749-Ab	Anti-GDF-8/MSTN monoclonal antibody	mab	Biofunctional antibody, Therapeutics Target antibody