Rat Nf2/merlin ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_013193.1)

Pre-made Rat Nf2/merlin Adeno-associated virus expression plasmid (ITR-vector) for Nf2 AAV packaging, Nf2 AAV production.The purified Rat Nf2/merlin AAV particle serves as an invaluable asset for in-depth in vivo Nf2 studies, mechanism of action (MOA) research, and the evolution of Nf2-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

Target products collectionGo to NF2/Nf2/merlin products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)



Product information

Catalog No. Product Name Plasmid Grade Plasmid quantity
pGMAAV000184 Rat Nf2 Adeno-associate virus(AAV) plasmid Research Grade 10mg, 50mg, 100mg, 500mg, >1g
GMP-like Grade 10mg, 50mg, 100mg, 500mg, >1g
High Quality (HQ) Grade
Seed 5ug


Product Description

Catalog ID pGMAAV000184
Gene Name Nf2
Accession Number NM_013193.1
Gene ID 25744
Species Rat
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 1776 bp
Gene Alias merlin
Fluorescent Reporter EGFP
Mammalian Cell Selection
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T95742-Ab Anti-MERL/ NF2/ ACN monoclonal antibody
    Target Antigen GM-Tg-g-T95742-Ag NF2 VLP (virus-like particle)
    ORF Viral Vector pGMAAV000184 Rat Nf2 Adeno-associate virus(AAV) plasmid
    ORF Viral Vector pGMAP000183 Human NF2 Adenovirus plasmid
    ORF Viral Vector vGMAAV000184 Rat Nf2 Adeno-associate virus(AAV) particle
    ORF Viral Vector vGMAP000183 Human NF2 Adenovirus particle
    ORF Viral Vector pGMLV002456 Human NF2 Lentivirus plasmid


    Target information

    Target ID GM-T95742
    Target Name NF2
    Gene ID 4771, 18016, 714945, 25744, 101087787, 477535, 540479, 100058977
    Gene Symbol and Synonyms ACN,BANF,merlin,merlin-1,NF2,SCH,SWNV
    Uniprot Accession P35240
    Uniprot Entry Name MERL_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target
    Disease Cancer
    Gene Ensembl ENSG00000186575
    Target Classification Tumor-associated antigen (TAA)

    This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022]



    About GMVC

    GDU



    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.