Rat Xbp1/HTF ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_001271731.1)

Pre-made Rat Xbp1/HTF Adeno-associated virus expression plasmid (ITR-vector) for Xbp1 AAV packaging, Xbp1 AAV production.The purified Rat Xbp1/HTF AAV particle serves as an invaluable asset for in-depth in vivo Xbp1 studies, mechanism of action (MOA) research, and the evolution of Xbp1-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

Target products collectionGo to XBP1/Xbp1/HTF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)



Product information

Catalog No. Product Name Plasmid Grade Plasmid quantity
pGMAAV000330 Rat Xbp1 Adeno-associate virus(AAV) plasmid Research Grade 10mg, 50mg, 100mg, 500mg, >1g
GMP-like Grade 10mg, 50mg, 100mg, 500mg, >1g
High Quality (HQ) Grade
Seed 5ug


Product Description

Catalog ID pGMAAV000330
Gene Name Xbp1
Accession Number NM_001271731.1
Gene ID 289754
Species Rat
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 1116 bp
Gene Alias HTF
Fluorescent Reporter EGFP
Mammalian Cell Selection
Fusion Tag Null
Promoter CMV
Resistance Amplicin

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-IP2282-Ab Anti-XBP1 monoclonal antibody
    Target Antigen GM-Tg-g-IP2282-Ag XBP1 protein
    ORF Viral Vector pGMLV001207 Human XBP1 Lentivirus plasmid
    ORF Viral Vector pGMAAV000330 Rat Xbp1 Adeno-associate virus(AAV) plasmid
    ORF Viral Vector pGMPC000167 Human XBP1 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLV001207 Human XBP1 Lentivirus particle
    ORF Viral Vector vGMAAV000330 Rat Xbp1 Adeno-associate virus(AAV) particle
    ORF Viral Vector pGMLV002092 Human XBP1 Lentivirus plasmid
    ORF Viral Vector pGMLV002367 Human XBP1 Lentivirus plasmid


    Target information

    Target ID GM-IP2282
    Target Name XBP1
    Gene ID 7494, 22433, 713863, 289754, 101092150, 477532, 541236, 100059209
    Gene Symbol and Synonyms D11Ertd39e,HTF,TREB-5,TREB5,XBP-1,XBP1,XBP1P1,XBP2,XBPP1
    Uniprot Accession P17861
    Uniprot Entry Name XBP1_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Not Available
    Disease Breast Cancer
    Gene Ensembl ENSG00000100219
    Target Classification Pathway

    This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]



    About GMVC

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    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.