Rat Nr1i3/CAR ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_022941.4)
Pre-made Rat Nr1i3/CAR Adeno-associated virus expression plasmid (ITR-vector) for Nr1i3 AAV packaging, Nr1i3 AAV production.The purified Rat Nr1i3/CAR AAV particle serves as an invaluable asset for in-depth in vivo Nr1i3 studies, mechanism of action (MOA) research, and the evolution of Nr1i3-associated gene therapy strategies.
Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.
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Product information
Catalog No. | Product Name | Plasmid Grade | Plasmid quantity |
---|---|---|---|
pGMAAV000746 | Rat Nr1i3 Adeno-associate virus(AAV) plasmid | Research Grade | 10mg, 50mg, 100mg, 500mg, >1g |
GMP-like Grade | 10mg, 50mg, 100mg, 500mg, >1g | ||
High Quality (HQ) Grade | |||
Seed | 5ug |
Product Description
Catalog ID | pGMAAV000746 |
Gene Name | Nr1i3 |
Accession Number | NM_022941.4 |
Gene ID | 65035 |
Species | Rat |
Product Type | Adeno-associate virus(AAV) plasmid (overexpression) |
Insert Length | 1077 bp |
Gene Alias | CAR |
Fluorescent Reporter | ZsGreen |
Mammalian Cell Selection | Puromyocin |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Sequence | ATGACAGCTACTCTAACACTAGAGACCATGACCAGTGAAGAAGAGTATGGGCCAAGGAACTGTGTGGTGTGTGGAGACCGAGCCACGGGCTATCATTTCCATGCCCTGACTTGTGAGGGCTGCAAAGGCTTTTTCAGACGAACAGTCAGCAAGACCATTGGTCCCATCTGTCCGTTTGCTGGGAGGTGTGAGGTCAGCAAGGCCCAGAGACGCCATTGTCCAGCCTGCAGGTTGCAGAAGTGTCTAAATGTTGGCATGAGGAAAGACATGATACTGTCAGCAGAAGCCCTGGCACTGCGGAGAGCCAGACAGGCACGGCGGCGGGCACAGAAAGCATCTTTGCAACTGAGTCAGCAGCAGAAAGAGCTCATCCAGACCCTCCTGGGCGCCCACACTCGTCATGTGGGCCCCATGTTTGACCAGTTTGTGCAGTTCAGGCCTCCGGCCTACCTGTTCAGCCATCACCGGCCTTTCCAGCCCCTGGCCCCCGTGTTGCCTCTGCTCACACACTTTGCAGATATCAATACTTTCATGGTGCAGCAGATTATCAAGTTCACCAAGGATCTGCCCCTTTTCCGTTCCCTGACCATGGAGGACCAGATCTCCCTTCTCAAGGGAGCGGCTGTGGAAATCTTGCATATCTCACTCAACACTACGTTCTGCCTTCAAACACAGAATTTCTTCTGCGGGCCCCTTTGCTACAAGATGGAAGATGCGGTCCATGTAGGGTTCCAGTACGAGTTTTTGGAGTTGATCATCCACTTCCACAAAACCCTGAAAAGATTGCAGCTCCAGGAGCCCGAGTATGCGCTCATGGCTGCCATGGCTCTCTTCTCTCCTGACAGGCCTGGGGTTACCCAAAGAGAAGAGATTGATCAGCTGCAGGAAGAGGTCGCGCTGATCCTCAACAACCACATTATGGAGCAACAGTCAAGACTCCAAAGTCGGTTTCTGTATGCAAAGCTGATGGGCCTGCTAGCTGAGCTTCGGAGTATAAACAGCGCATACTCATATGAAATCCATCGCATCCAGGGACTGTCTGCTATGATGCCGCTGCTTGGGGAGATTTGCAGCTGA |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
---|---|---|
Target Antibody | GM-Tg-g-T69506-Ab | Anti-NR1I3 monoclonal antibody |
Target Antigen | GM-Tg-g-T69506-Ag | NR1I3 protein |
ORF Viral Vector | pGMAD000501 | Human NR1I3 Adenovirus plasmid |
ORF Viral Vector | pGMAAV000746 | Rat Nr1i3 Adeno-associate virus(AAV) plasmid |
ORF Viral Vector | pGMLP002652 | Human NR1I3 Lentivirus plasmid |
ORF Viral Vector | pGMAP000504 | Human NR1I3 Adenovirus plasmid |
ORF Viral Vector | vGMAD000501 | Human NR1I3 Adenovirus particle |
ORF Viral Vector | vGMAAV000746 | Rat Nr1i3 Adeno-associate virus(AAV) particle |
ORF Viral Vector | vGMLP002652 | Human NR1I3 Lentivirus particle |
ORF Viral Vector | vGMAP000504 | Human NR1I3 Adenovirus particle |
Target information
Target ID | GM-T69506 |
Target Name | NR1I3 |
Gene ID | 9970, 12355, 574249, 65035, 101088457, 488653, 493711, 100066015 |
Gene Symbol and Synonyms | CAR,CAR-beta,CAR1,Care2,ESTM32,MB67,NR1I3 |
Uniprot Accession | Q14994 |
Uniprot Entry Name | NR1I3_HUMAN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Not Available |
Gene Ensembl | ENSG00000143257 |
Target Classification | Not Available |
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
About GMVC
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