Rat App/Abeta ORF/cDNA clone-Adenovirus plasmid (NM_019288.2)
Pre-made Rat App/Abeta adenoviral expression plasmid for App adenovirus packaging, App adenovirus.
Our GM-Adenovirus vector is optimized with the GMVC-modified Adeasy adenovirus packaging system. Find more about the GMVC-modified adenovirus packaging system.
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Product information
Catalog No. | Product Name | Plasmid Grade | Plasmid quantity |
---|---|---|---|
pGMAD001157 | Rat App Adenovirus plasmid | Research Grade | 10mg, 50mg, 100mg, 500mg, >1g |
GMP-like Grade | 10mg, 50mg, 100mg, 500mg, >1g | ||
High Quality (HQ) Grade | |||
Seed | 5ug |
Product Description
Catalog ID | pGMAD001157 |
Gene Name | App |
Accession Number | NM_019288.2 |
Gene ID | 54226 |
Species | Rat |
Product Type | Adenovirus plasmid (overexpression) |
Insert Length | 2313 bp |
Gene Alias | Abeta |
Fluorescent Reporter | |
Mammalian Cell Selection | Null |
Fusion Tag | 3xflag (C-Terminal) |
Promoter | CMV |
Resistance | Amplicin |
Sequence | ATGCTGCCCAGCCTGGCACTGCTCCTGCTGGCCGCCTGGACGGTTCGGGCTCTGGAGGTGCCCACTGATGGCAATGCCGGTCTGCTGGCAGAACCCCAGATCGCCATGTTCTGTGGTAAACTCAACATGCACATGAATGTGCAGAATGGAAAATGGGAGTCAGACCCATCAGGGACCAAAACCTGCATTGGCACCAAGGAGGGAATCCTGCAGTACTGCCAAGAGGTCTACCCTGAACTGCAGATCACAAACGTGGTGGAAGCCAACCAGCCAGTGACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACGCACACCCACATCGTGATTCCTTACCGGTGCCTAGTTGGTGAGTTTGTAAGCGATGCCCTTCTCGTGCCCGACAAGTGCAAGTTTCTACACCAGGAGCGGATGGACGTTTGTGAGACCCATCTTCACTGGCATACTGTTGCCAAAGAGACATGCAGTGAGAAGAGCACTAACTTGCACGACTATGGCATGCTGCTGCCCTGTGGCATCGACAAGTTCCGAGGGGTCGAGTTCGTGTGCTGCCCGTTGGCGGAGGAGAGCGACAGCATCGATTCTGCGGACGCAGAGGAGGACGACTCCGATGTCTGGTGGGGTGGAGCGGACACAGACTATGCTGATGGCGGTGAAGACAAAGTCGTAGAAGTAGCCGAAGAGGAGGAAGTGGCCGATGTTGAGGAAGAAGAAGCTGAGGATGACGAGGATGTGGAGGATGGGGATGAGGTGGAGGAGGAGGCCGAGGAGCCCTACGAAGAGGCCACAGAGAGAACAACCAGCATTGCCACCACTACCACAACTACCACTGAGTCTGTGGAGGAGGTAGTCCGAGAGGTGTGCTCTGAACAAGCTGAGACCGGGCCATGCCGTGCAATGATCTCCCGCTGGTACTTTGATGTCACTGAAGGAAAGTGCGCCCCATTCTTTTACGGCGGATGTGGCGGCAACAGGAACAACTTTGACACTGAAGAGTACTGCATGGCGGTGTGTGGCAGCGTGTCATCCCAAAGTTTACTCAAGACTACCAGTGAACCTCTTCCCCAAGATCCGGTTAAACTTCCCACGACGGCAGCCAGCACCCCTGACGCAGTCGACAAGTACCTGGAGACCCCCGGAGATGAGAACGAGCACGCCCATTTCCAGAAAGCCAAAGAGAGGTTGGAAGCCAAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAGGAGGCAGAACGTCAAGCCAAGAATTTGCCCAAAGCTGACAAGAAGGCCGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTCTGGAACAGGAAGCAGCCAACGAGAGGCAGCAGCTTGTAGAGACACACATGGCCAGAGTTGAAGCCATGCTCAATGATCGCCGTCGCCTGGCCCTCGAGAATTACATCACCGCACTGCAGGCGGTGCCTCCAAGGCCTCATCATGTGTTCAACATGCTGAAGAAGTACGTCCGTGCAGAGCAGAAGGACAGACAGCACACCCTAAAGCATTTTGAACATGTGCGCATGGTGGACCCCAAGAAAGCTGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATCTACGAGCGCATGAACCAGTCTCTGTCCCTGCTCTACAACGTCCCTGCCGTGGCTGAGGAGATTCAAGATGAAGTTGACGAGCTGCTTCAGAAGGAGCAGAACTACTCCGACGACGTCTTAGCCAACATGATCAGTGAACCCAGAATCAGTTACGGCAACGATGCTCTCATGCCTTCTTTGACTGAAACGAAGACCACTGTGGAGCTCCTTCCCGTGAATGGCGAATTCAGCCTGGATGATCTCCAACCGTGGCATCCTTTTGGGGTGGACTCTGTGCCAGCCAATACAGAAAATGAAGTTGAGCCTGTCGACGCCCGCCCCGCTGCTGACCGAGGACTGACCACTCGACCAGGGTCTGGGTTGACAAACATCAAGACAGAAGAGATCTCAGAAGTGAAGATGGATGCGGAGTTCGGACATGATTCAGGCTTCGAAGTCCGCCATCAAAAACTGGTGTTCTTTGCAGAAGATGTGGGTTCAAACAAAGGTGCCATCATTGGACTCATGGTGGGTGGCGTTGTCATAGCAACAGTGATTGTCATCACCTTGGTGATGCTGAAGAAGAAACAGTACACATCCATCCATCATGGCGTGGTGGAGGTTGACGCTGCTGTGACCCCGGAGGAGCGCCACCTCTCCAAGATGCAGCAGAATGGATATGAGAATCCAACATACAAGTTCTTTGAGCAGATGCAGAACTAA |
Reference
Data / case study
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Associated products
Target information
Target ID | GM-T87024 |
Target Name | APP |
Gene ID | 351, 11820, 100427716, 54226, 101085564, 403407, 280722, 100066294 |
Gene Symbol and Synonyms | AAA,ABETA,ABPP,AD1,Adap,Ag,alpha-sAPP,APP,APPI,betaApp,CTFgamma,CVAP,E030013M08Rik,PN-II,PN2,preA4 |
Uniprot Accession | P05067 |
Uniprot Entry Name | A4_HUMAN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, INN Index |
Disease | Not Available |
Gene Ensembl | ENSG00000142192 |
Target Classification | Not Available |
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
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