Rat Esr1/ER-alpha/ Esr ORF/cDNA clone-Adeno-associate virus(AAV) particle (NM_012689)

Pre-made Rat Esr1/ER-alpha/ Esr Adeno-associated virus particle for Esr1 in-vivo study, mechanism of action (MOA) research and Esr1-associated gene therapy development.

At GM Vector Core (GMVC), we stand at the forefront of custom AAV development and produce distinct grades of AAVs employing state-of-the-art methodologies. Uncover more about our expertise.

Target products collectionGo to ESR/Esr1/ER-alpha products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)



Product information

Catalog No. Product Name AAV serotype AAV Grade AAV quantity
vGMAAV000280 Rat Esr1 Adeno-associate virus(AAV) particle AAV1, AAV2, AAV2 variant (Y444F), AAV2 variant (Y272F, Y444F, Y500F, Y730F), AAV2 variant (Y444F, Y730F, Y500F, Y272F, Y704F, Y252F), AAV2 variant(AAV2.7m8), AAV5, AAV6, AAV8, AAV8-1m, AAV8-2m, AAV8 variant (Y733F, Y447F, Y275), AAV9, AAV-Rh.10, AAV-DJ, AAV-DJ/8, AAV-Retro (Retrograde), AAV9-PHP.B, AAV9-PHP.eB, AAV9-PHP.S, AAV-BR1, AAV-2i8, AAV-SIG, AAV-VEC, AAV4, AAV6.2, AAV6.2FF Pilot Grade 1.0E+12VG/ml
5.0E+12VG/ml
1E+13VG/ml
5E+13VG/ml
1E+14VG/ml
Research Grade 1.0E+12VG/ml
5.0E+12VG/ml
1E+13VG/ml
5E+13VG/ml
1E+14VG/ml
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMAAV000280
Gene Name Esr1
Accession Number NM_012689
Gene ID 24890
Species Rat
Product Type Adeno-associate virus(AAV) particle (overexpression)
Insert Length 1803 bp
Gene Alias ER-alpha, Esr, RNESTROR
Fluorescent Reporter EGFP
Mammalian Cell Selection
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T89534-Ab Anti-ESR monoclonal antibody
    Target Antigen GM-Tg-g-T89534-Ag ESR/ESR1 protein
    ORF Viral Vector pGMAAV000280 Rat Esr1 Adeno-associate virus(AAV) plasmid
    ORF Viral Vector pGMAP000547 Human ESR1 Adenovirus plasmid
    ORF Viral Vector vGMAAV000280 Rat Esr1 Adeno-associate virus(AAV) particle
    ORF Viral Vector vGMAP000547 Human ESR1 Adenovirus particle


    Target information

    Target ID GM-T89534
    Target Name ESR
    Gene ID 2099, 13982, 613025, 24890, 552888, 403640, 407238, 791249
    Gene Symbol and Synonyms ER,ER-alpha,Era,ERalpha,ESR,ESR1,ESRA,Estr,Estra,ESTRR,NR3A1,RNESTROR
    Uniprot Accession P03372
    Uniprot Entry Name ESR1_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Breast Cancer
    Gene Ensembl ENSG00000091831
    Target Classification Nuclear Receptors

    This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020]



    About GMVC

    GDU



    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.