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Anti-BCL-2 monoclonal antibody
Pre-made anti-BCL-2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to BCL-2/BCL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0014-Ab-1/ GM-Tg-hg-IP0014-Ab-2 | Anti-Human BCL-2/BCL2 monoclonal antibody | Human |
| GM-Tg-rg-IP0014-Ab-1/ GM-Tg-rg-IP0014-Ab-2 | Anti-Rat BCL-2/BCL2 monoclonal antibody | Rat |
| GM-Tg-mg-IP0014-Ab-1/ GM-Tg-mg-IP0014-Ab-2 | Anti-Mouse BCL-2/BCL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0014-Ab-1/ GM-Tg-cynog-IP0014-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BCL-2/BCL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0014-Ab-1/ GM-Tg-felg-IP0014-Ab-2 | Anti-Feline BCL-2/BCL2 monoclonal antibody | Feline |
| GM-Tg-cang-IP0014-Ab-1/ GM-Tg-cang-IP0014-Ab-2 | Anti-Canine BCL-2/BCL2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0014-Ab-1/ GM-Tg-bovg-IP0014-Ab-2 | Anti-Bovine BCL-2/BCL2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0014-Ab-1/ GM-Tg-equg-IP0014-Ab-2 | Anti-Equine BCL-2/BCL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0014-Ab-1/ GM-Tg-hg-IP0014-Ab-2; GM-Tg-rg-IP0014-Ab-1/ GM-Tg-rg-IP0014-Ab-2; GM-Tg-mg-IP0014-Ab-1/ GM-Tg-mg-IP0014-Ab-2; GM-Tg-cynog-IP0014-Ab-1/ GM-Tg-cynog-IP0014-Ab-2; GM-Tg-felg-IP0014-Ab-1/ GM-Tg-felg-IP0014-Ab-2; GM-Tg-cang-IP0014-Ab-1/ GM-Tg-cang-IP0014-Ab-2; GM-Tg-bovg-IP0014-Ab-1/ GM-Tg-bovg-IP0014-Ab-2; GM-Tg-equg-IP0014-Ab-1/ GM-Tg-equg-IP0014-Ab-2 |
| Products Name | Anti-BCL-2/BCL2 monoclonal antibody |
| Format | mab |
| Target Name | BCL-2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-BCL-2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0014-Ag-1 | Recombinant multi-species BCL2/ BCL-2/ Bcl-2 protein |
| ORF Viral Vector | vGMLP002721 | human BCL2 Lentivirus particle |
| ORF Viral Vector | pGMLP002721 | human BCL2 Lentivirus plasmid |
Target information
| Target ID | GM-IP0014 |
| Target Name | BCL-2 |
| Gene ID | 596,12043,24224,707407,403416,493934,281020,100050934 |
| Gene Symbol and Synonyms | Bcl-2,BCL2,C430015F12Rik,D630044D05Rik,D830018M01Rik,PPP1R50 |
| Uniprot Accession | P10415,P49950,Q6R755,O02718 |
| Uniprot Entry Name | BCL2_HUMAN,BCL2_RAT,BCL2_CANLF,BCL2_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Breast Cancer, immune cells or tumors |
| Gene Ensembl | ENSG00000171791 |
| Target Classification | Checkpoint-Immuno Oncology, Apoptosis |
The target: BCL-2, gene name: BCL2, also named as Bcl-2, PPP1R50. This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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