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Anti-TYR monoclonal antibody
Pre-made anti-TYR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TYR/TYR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0016-Ab-1/ GM-Tg-hg-IP0016-Ab-2 | Anti-Human TYR monoclonal antibody | Human |
| GM-Tg-rg-IP0016-Ab-1/ GM-Tg-rg-IP0016-Ab-2 | Anti-Rat TYR monoclonal antibody | Rat |
| GM-Tg-mg-IP0016-Ab-1/ GM-Tg-mg-IP0016-Ab-2 | Anti-Mouse TYR monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0016-Ab-1/ GM-Tg-cynog-IP0016-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TYR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0016-Ab-1/ GM-Tg-felg-IP0016-Ab-2 | Anti-Feline TYR monoclonal antibody | Feline |
| GM-Tg-cang-IP0016-Ab-1/ GM-Tg-cang-IP0016-Ab-2 | Anti-Canine TYR monoclonal antibody | Canine |
| GM-Tg-bovg-IP0016-Ab-1/ GM-Tg-bovg-IP0016-Ab-2 | Anti-Bovine TYR monoclonal antibody | Bovine |
| GM-Tg-equg-IP0016-Ab-1/ GM-Tg-equg-IP0016-Ab-2 | Anti-Equine TYR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0016-Ab-1/ GM-Tg-hg-IP0016-Ab-2; GM-Tg-rg-IP0016-Ab-1/ GM-Tg-rg-IP0016-Ab-2; GM-Tg-mg-IP0016-Ab-1/ GM-Tg-mg-IP0016-Ab-2; GM-Tg-cynog-IP0016-Ab-1/ GM-Tg-cynog-IP0016-Ab-2; GM-Tg-felg-IP0016-Ab-1/ GM-Tg-felg-IP0016-Ab-2; GM-Tg-cang-IP0016-Ab-1/ GM-Tg-cang-IP0016-Ab-2; GM-Tg-bovg-IP0016-Ab-1/ GM-Tg-bovg-IP0016-Ab-2; GM-Tg-equg-IP0016-Ab-1/ GM-Tg-equg-IP0016-Ab-2 |
| Products Name | Anti-TYR monoclonal antibody |
| Format | mab |
| Target Name | TYR |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TYR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0016-Ag-1 | Recombinant multi-species TYRO/ TYR/ ATN protein |
| ORF Viral Vector | vGMAP000437 | Human TYR Adenovirus particle |
| ORF Viral Vector | pGMAP000129 | Human TYR Adenovirus plasmid |
| ORF Viral Vector | pGMAP000437 | Human TYR Adenovirus plasmid |
| ORF Viral Vector | vGMAP000129 | Human TYR Adenovirus particle |
Target information
| Target ID | GM-IP0016 |
| Target Name | TYR |
| Gene ID | 7299,22173,308800,705792,403405,751100,280951,100060227 |
| Gene Symbol and Synonyms | albino,ATN,c,CMM8,OCA1,OCA1A,OCAIA,SHEP3,skc35,TYR |
| Uniprot Accession | P14679,P54834,P55033,Q8MIU0 |
| Uniprot Entry Name | TYRO_HUMAN,TYRO_FELCA,TYRO_CANLF,TYRO_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000077498 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TYR, gene name: TYR, also named as ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3. The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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