Anti-DHODH monoclonal antibody

Pre-made anti-DHODH monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to DHODH/DHODH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0021-Ab-1/ GM-Tg-hg-IP0021-Ab-2Anti-Human DHODH monoclonal antibodyHuman
GM-Tg-rg-IP0021-Ab-1/ GM-Tg-rg-IP0021-Ab-2Anti-Rat DHODH monoclonal antibodyRat
GM-Tg-mg-IP0021-Ab-1/ GM-Tg-mg-IP0021-Ab-2Anti-Mouse DHODH monoclonal antibodyMouse
GM-Tg-cynog-IP0021-Ab-1/ GM-Tg-cynog-IP0021-Ab-2Anti-Cynomolgus/ Rhesus macaque DHODH monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0021-Ab-1/ GM-Tg-felg-IP0021-Ab-2Anti-Feline DHODH monoclonal antibodyFeline
GM-Tg-cang-IP0021-Ab-1/ GM-Tg-cang-IP0021-Ab-2Anti-Canine DHODH monoclonal antibodyCanine
GM-Tg-bovg-IP0021-Ab-1/ GM-Tg-bovg-IP0021-Ab-2Anti-Bovine DHODH monoclonal antibodyBovine
GM-Tg-equg-IP0021-Ab-1/ GM-Tg-equg-IP0021-Ab-2Anti-Equine DHODH monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP0021-Ab-1/ GM-Tg-hg-IP0021-Ab-2; GM-Tg-rg-IP0021-Ab-1/ GM-Tg-rg-IP0021-Ab-2;
GM-Tg-mg-IP0021-Ab-1/ GM-Tg-mg-IP0021-Ab-2; GM-Tg-cynog-IP0021-Ab-1/ GM-Tg-cynog-IP0021-Ab-2;
GM-Tg-felg-IP0021-Ab-1/ GM-Tg-felg-IP0021-Ab-2; GM-Tg-cang-IP0021-Ab-1/ GM-Tg-cang-IP0021-Ab-2;
GM-Tg-bovg-IP0021-Ab-1/ GM-Tg-bovg-IP0021-Ab-2; GM-Tg-equg-IP0021-Ab-1/ GM-Tg-equg-IP0021-Ab-2
Products NameAnti-DHODH monoclonal antibody
Formatmab
Target NameDHODH
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-DHODH monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0021-Ag-1Recombinant multi-species PYRD/ DHODH/ DHOdehase protein
    ORF Viral VectorpGMLPm004283mouse Dhodh Lentivirus plasmid
    ORF Viral VectorvGMLPm004283mouse Dhodh Lentivirus particle


    Target information

    Target IDGM-IP0021
    Target NameDHODH
    Gene ID1723,56749,65156,706936,610755,101100354,533873,100067925
    Gene Symbol and Synonyms2810417D19Rik,DHOdehase,DHODH,POADS,URA1
    Uniprot AccessionQ02127,Q63707,Q5E9W3
    Uniprot Entry NamePYRD_HUMAN,PYRD_RAT,PYRD_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000102967
    Target ClassificationN/A

    The target: DHODH, gene name: DHODH, also named as DHOdehase, POADS, URA1. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.