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Anti-GGCX monoclonal antibody
Pre-made anti-GGCX monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to GGCX/GGCX products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0024-Ab-1/ GM-Tg-hg-IP0024-Ab-2 | Anti-Human GGCX monoclonal antibody | Human |
| GM-Tg-rg-IP0024-Ab-1/ GM-Tg-rg-IP0024-Ab-2 | Anti-Rat GGCX monoclonal antibody | Rat |
| GM-Tg-mg-IP0024-Ab-1/ GM-Tg-mg-IP0024-Ab-2 | Anti-Mouse GGCX monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0024-Ab-1/ GM-Tg-cynog-IP0024-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GGCX monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0024-Ab-1/ GM-Tg-felg-IP0024-Ab-2 | Anti-Feline GGCX monoclonal antibody | Feline |
| GM-Tg-cang-IP0024-Ab-1/ GM-Tg-cang-IP0024-Ab-2 | Anti-Canine GGCX monoclonal antibody | Canine |
| GM-Tg-bovg-IP0024-Ab-1/ GM-Tg-bovg-IP0024-Ab-2 | Anti-Bovine GGCX monoclonal antibody | Bovine |
| GM-Tg-equg-IP0024-Ab-1/ GM-Tg-equg-IP0024-Ab-2 | Anti-Equine GGCX monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0024-Ab-1/ GM-Tg-hg-IP0024-Ab-2; GM-Tg-rg-IP0024-Ab-1/ GM-Tg-rg-IP0024-Ab-2; GM-Tg-mg-IP0024-Ab-1/ GM-Tg-mg-IP0024-Ab-2; GM-Tg-cynog-IP0024-Ab-1/ GM-Tg-cynog-IP0024-Ab-2; GM-Tg-felg-IP0024-Ab-1/ GM-Tg-felg-IP0024-Ab-2; GM-Tg-cang-IP0024-Ab-1/ GM-Tg-cang-IP0024-Ab-2; GM-Tg-bovg-IP0024-Ab-1/ GM-Tg-bovg-IP0024-Ab-2; GM-Tg-equg-IP0024-Ab-1/ GM-Tg-equg-IP0024-Ab-2 |
| Products Name | Anti-GGCX monoclonal antibody |
| Format | mab |
| Target Name | GGCX |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-GGCX monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0024-Ag-1 | Recombinant multi-species VKGC/ GGCX/ VKCFD1 protein |
Target information
| Target ID | GM-IP0024 |
| Target Name | GGCX |
| Gene ID | 2677,56316,81716,695628,475769,101085622,281190,100067312 |
| Gene Symbol and Synonyms | GGCX,VKCFD1 |
| Uniprot Accession | P38435,O88496,Q07175 |
| Uniprot Entry Name | VKGC_HUMAN,VKGC_RAT,VKGC_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000115486 |
| Target Classification | N/A |
The target: GGCX, gene name: GGCX, also named as VKCFD1. This gene encodes an integral membrane protein of the rough endoplasmic reticulum that carboxylates glutamate residues of vitamin K-dependent proteins to gamma carboxyl glutamate, a modification that is required for their activity. The vitamin K-dependent protein substrates have a propeptide that binds the enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting as co-substrates. Vitamin K-dependent proteins affect a number of physiologic processes including blood coagulation, prevention of vascular calcification, and inflammation. Allelic variants of this gene have been associated with pseudoxanthoma elasticum-like disorder with associated multiple coagulation factor deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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