Anti-C1R/ EDSPD1 functional antibody

Anti-C1R/ EDSPD1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to C1R/C1R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-SE1392-Ab-1/ GM-Tg-hg-SE1392-Ab-2Anti-Human C1R monoclonal antibodyHuman
GM-Tg-rg-SE1392-Ab-1/ GM-Tg-rg-SE1392-Ab-2Anti-Rat C1R monoclonal antibodyRat
GM-Tg-mg-SE1392-Ab-1/ GM-Tg-mg-SE1392-Ab-2Anti-Mouse C1R monoclonal antibodyMouse
GM-Tg-cynog-SE1392-Ab-1/ GM-Tg-cynog-SE1392-Ab-2Anti-Cynomolgus/ Rhesus macaque C1R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-SE1392-Ab-1/ GM-Tg-felg-SE1392-Ab-2Anti-Feline C1R monoclonal antibodyFeline
GM-Tg-cang-SE1392-Ab-1/ GM-Tg-cang-SE1392-Ab-2Anti-Canine C1R monoclonal antibodyCanine
GM-Tg-bovg-SE1392-Ab-1/ GM-Tg-bovg-SE1392-Ab-2Anti-Bovine C1R monoclonal antibodyBovine
GM-Tg-equg-SE1392-Ab-1/ GM-Tg-equg-SE1392-Ab-2Anti-Equine C1R monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg

Product Description

Catalog No.GM-Tg-hg-SE1392-Ab-1/ GM-Tg-hg-SE1392-Ab-2; GM-Tg-rg-SE1392-Ab-1/ GM-Tg-rg-SE1392-Ab-2;
GM-Tg-mg-SE1392-Ab-1/ GM-Tg-mg-SE1392-Ab-2; GM-Tg-cynog-SE1392-Ab-1/ GM-Tg-cynog-SE1392-Ab-2;
GM-Tg-felg-SE1392-Ab-1/ GM-Tg-felg-SE1392-Ab-2; GM-Tg-cang-SE1392-Ab-1/ GM-Tg-cang-SE1392-Ab-2;
GM-Tg-bovg-SE1392-Ab-1/ GM-Tg-bovg-SE1392-Ab-2; GM-Tg-equg-SE1392-Ab-1/ GM-Tg-equg-SE1392-Ab-2
Products NameAnti-C1R monoclonal antibody
Target NameC1R
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
Products descriptionPre-made anti-C1R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.


    Data / case study

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    Associated products

    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-SE1392-Ag-1Recombinant multi-species C1R/ EDSPD1 protein
    ORF Viral VectorpGMLPm004075mouse C1ra Lentivirus plasmid
    ORF Viral VectorvGMLPm004075mouse C1ra Lentivirus particle

    Target information

    Target IDGM-SE1392
    Target NameC1R
    Gene ID715,312705,477707,101088940,511581,100060297
    Gene Symbol and SynonymsC1R,EDS8,EDSPD1
    Uniprot AccessionP00736
    Uniprot Entry NameC1R_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    Gene EnsemblENSG00000159403
    Target ClassificationN/A

    The target: C1R, gene name: C1R, also named as EDSPD1. This gene encodes a member of the peptidase S1 protein family. The encoded protein is a proteolytic subunit in the complement system C1 complex. The complement system acts as a mediator in the innate immune response by ultimately triggering phagocytosis, inflammation, and rupturing the bacterial cell wall. Mutations in this gene are associated with Ehlers-Danlos Syndrome. [provided by RefSeq, Dec 2018].

    About Gmab


    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.